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This paper introduces EEPRS, a framework that improves polygenic risk prediction by integrating electronic health records through phenotype embeddings, showing significant performance gains over traditional methods.

The paper assesses the effectiveness of a genotyping array in detecting ash dieback tolerance and hybridization in common ash, finding limited success in identifying tolerance-associated SNPs but success in detecting hybrids and abiotic factor associations.

The paper identifies ampliconic sequences in mouse t-haplotypes as drivers of selfish transmission, showing their evolutionary relationship to sex chromosome dynamics.

This study shows that inhibiting REV1, a TLS polymerase, increases trinucleotide repeat instability in human cells, suggesting REV1 protects against TNR mutagenesis.

This study analyzes genomic profiles of drug resistance and virulence in Leishmania infantum isolates from the Mediterranean, identifying common resistance biomarkers and mechanisms.

This paper applies genomic prediction to wing morphology traits in Nasonia vitripennis using GBLUP and GBS data, finding higher accuracy in 5-fold cross-validation than across-generation validations.

This study examines how geography and forest management influence genetic diversity in saproxylic beetles using genomic data from central European forests.

The paper identifies eQTLs, rQTLs, and pQTLs in the human brain and shows that many eQTL effects are attenuated post-transcriptionally, yet still correlate with schizophrenia GWAS signals.

This study shows that the SCAN1 mutation H493R in TDP1 blocks repair of TOP1-induced DSBs in quiescent cells, leading to genome instability and cell death.

The paper introduces a method using multi-parent RILs crossed to a tester to dissect cis and trans regulation of gene expression in Drosophila, finding environmental and genetic trans effects in 31% and 19% of loci respectively.

The paper identifies plasma proteins associated with clonal hematopoiesis and links them to cardiovascular disease through proteomic and genetic analyses.

This study constructs a multi-tissue cell atlas of pigs, identifies cell-type-specific gene regulation, and links these to complex traits and human phenotypes.

This study identifies a nonsense mutation in the PRKG2 gene as the cause of chondrodysplasia in Dalmatian dogs, resolving a long-standing genetic mystery.

The paper introduces two fine-mapping methods to account for ancestral and environmental heterogeneity in GWAS, improving resolution of causal variants across diverse populations.

The paper identifies highly cell-type-specific eQTLs using snRNA-seq data from brain and blood, showing that bulk analyses overestimate eQTL agreement.

This study shows H3K4me2 regulates H2A.Z and Polycomb repressive marks in Arabidopsis, influencing transcriptional repression and chromatin dynamics.

This paper introduces a Bayesian framework for inferring population structure using IBD-based stochastic block models, showing improved accuracy over heuristic methods in both simulated and real data.

This paper introduces a hyperdCas12a-based CRISPR system for multiplexed gene regulation in Candida albicans, demonstrating its effectiveness in studying genetic interactions and drug resistance.

mfSuSiE improves fine-mapping of chromatin accessibility QTLs across multiple cell types and integrates multi-omic data in aging human brain samples.