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The paper introduces APCH, a method to identify pleiotropy across multiple traits and tissues by modeling heterogeneous effect sizes and subset-level inference.

The paper shows Scd6 and Edc3 redundantly work with Dhh1 to repress mRNA decay of starvation-induced pathways in yeast.

This paper uses experimental evolution to improve mother-daughter separation defects in brewing yeast by generating evolved strains with reduced clustering.

This study identifies that impaired ribosomal RNA biogenesis enhances resistance to reductive stress in C. elegans by reducing NADPH/NADH accumulation and GSH levels.

This study evaluates how well four ARG inference tools perform with phasing errors, finding they remain robust despite inaccuracies in haplotype phasing.

The paper identifies sheeppox virus in 17th-19th century French sheep remains using paleogenetics and interdisciplinary methods.

The paper identifies key transcription factors and their target proteins in renal cell carcinoma using multi-omic integration of ChIP-seq and GWAS data.

The paper examines how molecular interactions and activity-fitness functions determine phenotypic dominance in homomeric proteins.

The paper identifies a fractal genetic structure in curimba fish populations, revealing mixed stocks and the impact of dams on genetic diversity using genomic resources.

This study optimizes C. elegans cryopreservation by identifying the best developmental stage, cryoprotectant concentration, and storage conditions to achieve high survival rates across strains.

This paper identifies a molecular marker for sex determination in Syrian hamster pups using placental tissues, achieving 85% specificity in sex classification.

PRSNet-2 predicts complex phenotypes from genotypic data using a hierarchical graph neural network, outperforming baselines and reducing overfitting.

The paper identifies trans-acting mutations in yeast that modulate gene expression noise in both intrinsic and extrinsic ways, revealing non-nuclear factors influencing nuclear gene expression.

This paper identifies β-nicotinamide mononucleotide (NMN) as a naturally occurring broad-spectrum CRISPR inhibitor that targets multiple Cas proteins, reducing off-target effects and improving safety in genome editing.

The paper identifies INS-17 as a specific insulin-receptor ligand in C. elegans that regulates learning and memory independently of lifespan.

G4mer identifies G-quadruplexes and disease variants from population-scale genetic data, improving accuracy and highlighting sequence features affecting rG4 formation.

This paper presents a mouse model of ADSS1 myopathy by knocking out Adss1 and characterizes its motor deficits and histopathological features.

The paper identifies a non-coding variant causing GSD IX γ2, validates its splicing effects, and demonstrates reversal using antisense oligonucleotides.

CRISPR-All enables genome-scale, combinatorial genetic perturbations in human cells, revealing additive functional improvements through multiplexed modifications.

This study identifies osm-11's role in enhancing salinity stress tolerance in C. elegans by modulating fatty acid metabolism, cytochrome P450 pathways, and suppressing calcium signaling.