Coalescent theory of the {psi} directionality index
This paper develops theoretical predictions for the directionality index in coalescent models of two populations and analyzes its behavior in Drosophila melanogaster.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
This paper develops theoretical predictions for the directionality index in coalescent models of two populations and analyzes its behavior in Drosophila melanogaster.
Alyssa Bushey Long, Isabella M. Wilson, Tiffany T. Terry…·Tamara Caspary
This paper shows that expressing ARL13B-Cerulean rescues Arl13b-null mice from embryonic lethality but not fertility, indicating ARL13B's role in spermatogenesis.
Renzo Bonifazi, T.H.E. Meuwissen, Pascal Croiseau…·JACK J. WINDIG
This study examines the impact of genomic selection on genetic diversity in five European cattle breeds, finding inconsistent changes in inbreeding rates and highlighting the role of breeding strategies over GS itself.
Caitlin Lahue, Sriram Ravindran, Aryan Dalal…·Christoph D Rau
The paper identifies Serpina3n as a major regulator of cardiac gene expression in heart failure by integrating genetic and epigenetic data from mouse strains.
Dan Kaptijn, Corinna Losert, Maryna Korshevniuk…·Lude Franke
The paper identifies co-eQTLs that alter gene co-expression relationships in specific cell types, linking these variants to immune disease associations.
Keshav Kumar Meghwanshi, Chhavi Choudhary, Pooja Rohilla…·Jayendra Nath Shukla
This study identifies tssk homologues in Anopheles stephensi and Aedes aegypti, showing their male-specific expression and role in regulating protamine and mts gene expression through NAP interaction.
Marcos da Conceição, Juliana Barreto Albuquerque Pinto, Diego Pereira…·Fabiano Cordeiro Moreira
This study characterizes HERV expression in gastric cancer tissues and finds differential expression in tumor samples, particularly those with H. pylori infection.
Marine Vautier, Jonas Bylemans, Jean-Marc Baudoin…·Isabelle Domaizon
This study compares two eDNA sampling strategies in freshwater lakes, finding that the spatially integrated approach underestimates in-situ eDNA concentrations compared to the point sampling strategy.
Diego Pereira, Fabiano Cordeiro Moreira, Daniel de Souza Avelar…·Paulo Pimentel de Assumpção
The paper identifies viral species in gastric tumor and peritumoral tissues, finding enriched viruses and comparable diversity between tissue types.
Mahya Nasrollahi, Mojgan Bandehpour, Hojun Kim
This study investigates HPV-induced inflammation and cellular changes in cervical cancer, finding strong associations between high-risk HPV genotypes and severe inflammatory responses, particularly in younger individuals.
Pengfei Xu, You Wu, Qihui Wan, Xiang Yu
The paper identifies post-transcriptional mechanisms coordinating transcription and translation rhythms in Arabidopsis under circadian and stress conditions.
The paper develops a locus-specific HRM assay for analyzing DNA methylation in the SHANK3 gene and validates its performance on two HRM platforms.
Jung Hoon Yoon, Sellamuthu Karthi, Louise Prakash, Satya Prakash
This study shows WRN and WRNIP1 ATPases enhance the fidelity of Y-family DNA polymerase translesion synthesis by preventing nucleotide misincorporations.
William Timothy Treal Taylor, Nicolas Delsol, Vicky M. Oelze…·John Krigbaum
The paper uses archaeological and isotopic analysis to show that domestic horses and donkeys were transported to Jamestown, Virginia in 1606, with evidence of their use and consumption during the 'Starving Time' and the presence of a donkey with mixed European and West African ancestry.
Matthew Aguirre, Jeffrey P. Spence, Guy Sella, Jonathan K. Pritchard
The paper simulates gene regulatory networks and models perturbation effects to understand network structure and function.
Baojun De, Bowen Lei, Yuting Chen…·Junwei Cao
The paper integrates multi-omics data from Bactrian camels to identify regulatory mechanisms and genetic variants influencing muscle traits.
Felix Langschied, Matthias S. Leisegang, Stefan Günther…·Ingo Ebersberger
The paper investigates the impact of miRNA losses in rodents, showing multi-level gene regulation restructuring and evolutionary consequences.
Weizhao Sun, Clara Clinder, Mohammed Errbii…·Jan Buellesbach
This study investigates the role of the fas3 gene in regulating cuticular hydrocarbons in Nasonia vitripennis, showing its impact on survival and sexual communication.
Caíque Machado e Silva, Bharath Kunduru, Norbert T. Bokros…·Gota Morota
This study improves genomic prediction of stalk lodging resistance in maize by integrating multi-environment data, showing that multi-environment models significantly enhance prediction accuracy for most traits.
Irena Josephina Johanna Muffels, Rohit Budhraja, Rameen Shah…·Tamás Kozicz
This study identifies shared molecular signatures and potential therapeutic targets across multiple Congenital Disorders of Glycosylation using multi-omics integration and drug prediction.