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363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- GenomicsBioinformaticsPeer-reviewed
Colora: A Snakemake Workflow for Complete Chromosome-scale De Novo Genome Assembly
Lia Obinu, Tim Booth, Heleen De Weerd…·Andrea Porceddu
Colora provides a Snakemake workflow for automated, high-quality chromosome-scale de novo genome assembly using PacBio HiFi, Hi-C, and optionally ONT reads.
- GenomicsbioRxivPreprint
Large-scale identification of microsatellite loci from multiple otter (Mammalia, Carnivora, Lutrinae) species using whole genome sequence data
Vera de Ferran, Channelle Ee Eun Chua, Philip Johns…·Klaus‐Peter Koepfli
This study identifies microsatellite loci for 11 otter species using whole-genome sequences, validates their utility, and shows their applicability for genotyping and comparative studies.
DOI 10.1101/2025.04.14.648774 - GenomicsCommunications BiologyPeer-reviewed
Constructing a Draft Indian Cattle Pangenome Using Short-Read Sequencing
Sarwar Azam, Abhisek Sahu, Naveen Kumar Pandey…·Subeer S. Majumdar
This study constructs a draft pangenome for Indian desi cattle using short-read sequencing, identifying novel sequences that improve genetic variant discovery and mapping accuracy.
- GenomicsbioRxivPreprint
TD2: finding protein coding regions in transcripts
Alan Mao, Hyun Joo Ji, Brian J. Haas…·Markus J. Sommer
TD2 is a new tool for ab initio annotation of protein-coding ORFs in transcripts, showing sensitivity and precision across diverse eukaryotic transcriptomes.
5 citations - GenomicsGenome Biology and EvolutionPeer-reviewed
Chromosome-level genome assembly of the Asian tramp snail Bradybaena similaris (Stylommatophora: Camaenidae)
Yasuto Ishii, Atsushi Toyoda, Alec Lewis…·Satoshi Chiba
This paper presents a chromosome-level genome assembly and transcriptome for Bradybaena similaris, a terrestrial snail in the superfamily Helicoidea, enhancing genomic resources for evolutionary studies.
- GenomicsbioRxivPreprint
Mosaic accumulation of somatic genetic variation and estimates of age in the long-lived reef-building coral Acropora palmata
Trinity L. Conn, Jessie Renton, Valérie F. Chamberland…·Iliana B. Baums
The paper quantifies somatic genetic variation in corals and estimates their age using mutation rates, finding no positive selection and a neutral framework for studying genetic diversity.
- GenomicsbioRxivPreprint
Customizable host and viral transcript enrichment using CRISPR-Cas9 long-read sequencing for isoform discovery and validation
An N.T. Nguyen, Jianshu Zhang, Shuxin Zhang…·Lachlan Coin
This study uses CRISPR-Cas9 to enrich specific transcripts for long-read sequencing, enabling efficient and accurate isoform discovery and low abundance transcript detection.
- GenomicsbioRxivPreprint
Biologically-informed Interpretable Deep Learning Framework for Phenotype Prediction and Gene Interaction Detection
Chloe Catherine Hequet, Oscar E. Gaggiotti, Silvia Paracchini…·Juan Ye
This paper introduces GENEPAIR, a DNN interpretation framework for detecting gene-gene interactions in genomic data, demonstrating its ability to uncover both known and novel gene interactions related to BMI.
- GenomicsNucleic Acids ResearchPeer-reviewed
SOI: Robust identification of orthologous synteny with the Orthology Index and broad applications in evolutionary genomics
Rengang Zhang, Hong‐Yun Shang, RICHARD IAN MILNE…·Yongpeng Ma
This paper introduces the Orthology Index (OI) to robustly identify orthologous synteny, demonstrating its scalability and reliability across diverse polyploidization events and applications in plant evolutionary genomics.
- GenomicsJournal of HeredityPeer-reviewed
The genome assembly of the duckweed fern, Azolla caroliniana
Michael J. Song, Yanã Campos Rizzieri, Fay‐Wei Li…·Carl J. Rothfels
The paper presents a chromosome-level genome assembly of Azolla caroliniana, improving upon previous assemblies and aiding in understanding its population genetics and taxonomy.
- GenomicsJournal of Archaeological Science ReportsPeer-reviewed
A multidisciplinary investigation into whether Andean caravans reached the southern lowlands of the Parana-Plata basin during pre-Columbian times
Daniel Loponte, Alejandro Alberto Acosta, Tommaso Giovanardi…·Michael V. Westbury
The paper investigates whether Andean caravans reached the southern lowlands of the Parana-Plata basin during pre-Columbian times using multidisciplinary methods and finds no evidence of llama presence.
2 citations - GenomicsGigabytePeer-reviewed
Genome assembly and annotation of Acropora pulchra from Mo'orea French Polynesia
Trinity L. Conn, Jill Ashey, Ross Cunning, Hollie M. Putnam
The paper presents the genome and DNA methylome assembly of Acropora pulchra from Moorea, French Polynesia, achieving high completeness and providing insights into its genetic and epigenetic features.
- GenomicsbioRxivPreprint
Evidence of distal regulations orchestrated by RNAs initiating at short tandem repeats
Mathys Grapotte, Christophe Vroland, Diego Garrido-Martín…·Charles‐Henri Lecellier
The paper identifies RNA-initiating sites at STRs and links them to gene expression, revealing regulatory roles and interactions with Alu repeats.
2 citations - GenomicsMicrobiology SpectrumPeer-reviewed
Recent emergence of cephalosporin resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding blaCTX-M-15 gene
Tharani Priya Thirumoorthy, Jobin John Jacob, Aravind Velmurugan…·Balaji Veeraraghavan
15 citationstop 3% - GenomicsScientific ReportsPeer-reviewed
Endogenous Retrovirus Loci and Induced Changes in Gene Expression in Japanese Indigenous Chickens
Shinya Ishihara, Jun‐ichi Shiraishi, Saki Shimamoto, Daichi Ijiri
This study identifies ERV loci in three chicken breeds and finds their association with gene expression changes in specific genes.
- GenomicsbioRxivPreprint
A modified methyl transferase cofactor to selectively disable gene expression in E. coli
Oliver J. Irving, Samuel Stone, Robert K. Neely, Tim Albrecht
The paper demonstrates that AdoHcy azide modification selectively disables gene expression in E. coli by causing transcriptional steric inhibition.
DOI 10.1101/2025.04.10.648196 - GenomicsMolecular PsychiatryPeer-reviewed
Linked emergence of racial disparities in mental health and epigenetic biological aging across childhood and adolescence
M. Aikins, Yayouk Eva Willems, Deniz Fraemke…·Laurel Raffington
The paper examines the link between racial disparities in mental health and epigenetic biological aging across childhood and adolescence using a birth cohort study.
13 citationstop 1% - GenomicsbioRxivPreprint
Epigenetic Clocks Uncover the Natural History of Ageing in Wild Mice
Sarah E. Wolf, Simon A. Babayan, Riccardo Emilio Marioni…·Tom J. Little
This paper develops an epigenetic clock for wild wood mice to estimate age and ageing rates, showing slower ageing in supplemented and parasite-treated individuals.
DOI 10.1101/2025.04.09.648041