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This study identifies a fungal RNA-dependent RNA polymerase essential for cross-kingdom RNAi and pathogenicity in plant infection.

This study shows that deleting Ccl2 in smooth muscle cells does not reduce early atherosclerosis in mice, suggesting SMC-secreted CCL2 is not critical for plaque development.

This paper develops a machine learning model to quantify age-related histological changes in mouse kidneys, validated against pathologist scores and applied to provide reproducible age scores.

This study links mass mortality events in noble pen shells to picornavirus infection in haemocytes, suggesting immunosuppression as a potential cause.

This study tests if inhaled terazosin, an α1 adrenoreceptor antagonist, reduces lung fibrosis in animal models but finds no significant effect.

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

This study identifies an IgE/mast cell/B cell amplification loop that drives abdominal aortic aneurysm progression by promoting IL-4 production and subclinical fissure healing impairment.

This study analyzes G4 structures in bacterial pathogenicity islands and finds their non-random distribution and correlation with GC content, suggesting functional roles in DNA integration and pathogenicity.

This study shows that DC8 supplementation reduces AKI markers and promotes peroxisomal FAO over mitochondrial FAO in mice with kidney injury.

This paper introduces a modified RGB trichrome staining method (HemRGB) that improves nuclear staining for colorectal cancer histopathology.

This study identifies XeAvrRxo1 as a virulence and avirulence effector in X. euvesicatoria and shows that its chaperone Xe4429 suppresses toxicity, represses expression, and enhances secretion of XeAvrRxo1.

This paper develops machine learning models to infer spatial transcriptomics data from H&E-stained skin slides, improving the assessment of photoaging and its therapeutic implications.

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

This paper applies spatial transcriptomics data with contrastive crossmodal pretraining to improve graph-based deep learning models for cancer histopathology analysis.

This paper introduces OT-TP-LSM for 3D pathology, achieving high imaging depths and enabling virtual H&E image generation via deep learning.

This study identifies reduced Vip3Aa binding to midgut receptors as the resistance mechanism in a Vip3Aa-resistant strain of Helicoverpa zea.

This study identifies tissue-specific genetic responses to ophidiomycosis in snakes using transcriptome analysis, revealing chronic inflammation and temperature-dependent host responses.

This study examines SNCA transcription in neurons with different -syn cytopathologies in LBD, finding preserved transcripts in non-Lewy body types and reduced in Lewy bodies.

This study evaluates the impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection, finding that the treatment better preserves liver health compared to curative doses of benznidazole.

The paper introduces a deep learning model, MAXIM, to impute missing protein markers in multiplex images, improving efficiency in staining and imaging processes.