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This study shows that blocking IL-18 with IL-18BP improves cardiac function in mice on a Western diet, independent of weight gain and glucose tolerance.

The paper investigates heat calls in zebra finches, showing they are soft, frequency-modulated whistles produced during panting via laminar flow in the larynx.

This study shows that increasing JAG1 expression in dystrophin-deficient mice improves muscle size, strength, and myofiber number.

The paper investigates MYBPHL nonsense mutations, showing they impair sarcomere incorporation, lead to protein degradation, and cause contractile defects in cardiomyocytes.

This study identifies a Cx43 targeting peptide that inhibits neointima formation in both human and mouse models by blocking cyclin E interactions and cell cycle progression.

Controlled 8-hour indoor trials with 36 hydrated young adults establish empirical heat-survival maps across 32-35°C wet-bulb temperatures, showing uncompensable heat at 34-35°C and longer female endurance.

This paper develops an adaptive method for setting pressure boundary conditions in microvascular blood flow simulations and quantifies uncertainty in hemodynamic predictions across brain cortical networks.

This study shows that acute exogenous ketone monoester supplementation reduces cardiac vagal modulation in a dose-dependent manner in healthy adults.

This study shows that disrupting a regulatory element in the CEBPA gene of African turquoise killifish increases lifespan and healthspan by enhancing full-length C/EBP isoform activity.

This study shows that vitamin E and plant extracts reduce oxidative stress and inflammation in early lactating dairy cows.

This study shows mechanical loading induces muscle fiber growth through two mechanisms: mTORC1-dependent radial growth and mTORC1-independent longitudinal sarcomere addition.

This study shows that removing a specific splice variant of ClC-1 in a DM1 mouse model eliminates myotonia and improves muscle function and histology.

This study shows that aromatase in adipose tissue protects bone in male mice by regulating phosphate reabsorption via NaPi2 proteins.

This study examines how vitamin E and plant extracts affect immune response and mammary epithelium integrity in dairy cows during an LPS challenge, finding improved local immunity and mammary health.

This study shows that SG1002, an H2S prodrug, partially protects against erectile dysfunction caused by long-term androgen deprivation in mice.

This study identifies the dual role of the HPA axis in regulating energy homeostasis during cold exposure through ACTH-mediated thermogenesis and glucocorticoid-driven hyperphagia.

This study reveals a structural mechanism for thermosensing in TRPV3 channels, showing that extreme thermosensitivity arises from protein unfolding and dynamic changes rather than localized sensors.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study shows that loss of ovarian hormones alters EV nucleic acid content and skeletal muscle metabolism during acute exercise in female rats.