Ramy K. A. Sayed

This study shows that mTORC1 regulates myofibrillogenesis and radial myofibril growth in response to mechanical loading in mice.

This study identifies myofibril loss as the primary cause of muscle fiber atrophy in aging and disuse, using macroscopic to ultrastructural analyses in humans and mice.

This study shows mechanical loading induces muscle fiber growth through two mechanisms: mTORC1-dependent radial growth and mTORC1-independent longitudinal sarcomere addition.

This study develops a novel imaging method (FIM-ID) to show that myofibrillogenesis, not myofibril hypertrophy, drives mechanically induced skeletal muscle growth.