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Asymmetric migration shapes genetic structure of the invasive avian vampire fly (Philornis downsi) across the Galapagos Islands.

This study investigates the genetic structure and dispersal patterns of Philornis downsi across Galapagos Islands using whole genome sequencing, finding asymmetric gene flow and genetic divergence linked to trade winds and shipping routes.

Validation of a high throughput fluorescent Capillary Electrophoresis Sodium Dodecyl Sulfate method for monoclonal antibody size heterogeneity assessment

This study validates a fluorescence-based CE-SDS method for assessing monoclonal antibody size heterogeneity, showing high specificity and precision compared to UV-based methods.

An interferon-like off-switch in invertebrates: Vago4 downregulates Domeless to restrain JAK/STAT signaling

This study identifies Vago4 as a ligand that downregulates Domeless to restrain JAK/STAT signaling in invertebrates, defining an IFN-like axis.

Beyond single-trait analysis: ancient genomes reveal coordinated evolution of dietary endophenotypes in Holocene Europe

This study uses ancient genomes to show coordinated evolutionary changes in dietary endophenotypes across Holocene Europe.

Compost from urban biowaste shapes the bacterial community and its functional traits in the rhizosphere of tomato plants

This study shows that industrial compost from urban biowaste increases bacterial diversity and functional traits in tomato rhizosphere compared to chemical fertilizer.

One lysine, two acyl marks: 2-hydroxyisobutyrylation and acetylation of G6PD differ in outcome and regulation

This study investigates the site-specific effects of 2-hydroxyisobutyrylation and acetylation on G6PD activity and shows their distinct regulatory roles and deacylase recognition.

Pregnancy History and Loss of Normal PSEN2 Function Impact Female Late-Life Cognitive Processing, Inhibitory Signaling, and Gliosis

The paper investigates how pregnancy history and PSEN2 deficiency affect cognitive function and neurobiology in aged female mice, finding no synergistic effects.

Dysplastic Alveolar Basaloid Cells Provide a Protective Barrier via KRT17-Stratifin Complex during Chronic Fibrosis

The paper identifies KRT17-Stratifin complex as a protective barrier in dysplastic alveolar basaloid cells during chronic fibrosis, revealing mechanisms of alveolar metaplasia and its functional relevance.

Identification of TM4SF1 as a novel tumor-associated antigen in biliary tract cancers targetable by CAR-T cell therapy

This study identifies TM4SF1 as a tumor-associated antigen in biliary tract cancers and shows anti-TM4SF1 CAR-T cells inhibit tumor growth in vitro and in vivo.

Analysis of sperm processing and cryopreservation procedures in the common marmoset (Callithrix jacchus) to reduce fragmentation and maximize total and progressive motility

The paper optimizes sperm processing and cryopreservation methods in common marmosets to improve motility and reduce DNA fragmentation for IVF applications.

Negative sampling shapes benchmark discrimination and experimental retrieval in synthetic-lethality prediction

The paper evaluates how negative sampling affects synthetic-lethality prediction models, showing that benchmark performance does not reliably predict experimental retrieval success.

REM Sleep Misfires: Intruding Delta Waves Forecast Tau, Amyloid, and Forgetting in Aging

This study shows that aging and Alzheimer's disease are linked to changes in REM sleep delta waves, which are associated with memory decline and amyloid-beta and tau accumulation.

Conserved cell state dynamics reveal targetable resistance patterns in ovarian high-grade serous carcinoma

The paper identifies conserved cell states in ovarian high-grade serous carcinoma that correlate with poor prognosis and presents actionable targets for improving platinum response.

Soft Sensing of Intracellular States for CHO Cell Bioprocessing with Ensemble Kalman Filters

This paper uses Ensemble Kalman Filters to estimate intracellular nucleotide sugar donors in CHO cell cultures from extracellular measurements, improving metabolic state inference.

Dynamic Exchange of Bacteria and Carbapenem Resistance Genes between Sewer Biofilms and Wastewater

The paper investigates the exchange of bacteria and carbapenem resistance genes between sewer biofilms and wastewater under controlled and field conditions.

Machine learning-assisted Repli-Histo labeling reveals distinct transcription-dependent constraints on chromatin motion in living cells

The paper uses machine learning to classify chromatin classes and shows how different transcription systems affect nucleosome motion in distinct chromatin regions.

Kontext: Kernel-based method bridging spatial domain identification and cell-cell communication

Kontext identifies spatial domains and cell-cell communication by integrating ligand-receptor interactions, outperforming existing methods in spatial transcriptomics.

Deep Learning Based Cell Segmentation of 3D Confocal Images of Wood for Enzymatic Hydrolysis Applications

This paper develops a 3D U-net model for segmenting wood cells in confocal images to improve predictions of enzymatic hydrolysis efficiency.

Stream and lake network position structures freshwater microbial communities across multiple catchments

The paper shows bacterial community composition changes consistently across hydrological network positions in freshwater systems.

Transformer Language Models Reveal Distinct Patterns in Aphasia Subtypes and Recovery Trajectories

This paper uses GPT-2 to analyze aphasia subtypes and recovery by examining activation patterns in narrative speech over time, finding distinct differences across subtypes and changes during recovery.