Julia H. Pham

This study identifies TM4SF1 as a tumor-associated antigen in biliary tract cancers and shows anti-TM4SF1 CAR-T cells inhibit tumor growth in vitro and in vivo.

The paper constructs a single-cell and spatial atlas of prostate cancer to reveal gene modules driving lineage plasticity and metastasis, identifying new biological insights and a transformer-based model for cell-state classification.

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.

Single cell RNA sequencing of bladder cancer subtypes identified a CA125+ cell state linked to aggressive features and TM4SF1 as a therapeutic target.

This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.

This study uses single-cell RNA-seq to identify a luminal progenitor cell state in BPH linked to inflammation and MIF interactions.