Discover, rate, and discuss biology preprints.

The paper uses mathematical distances from HA sequences to forecast influenza vaccine effectiveness for the 2026--2027 season, predicting 40% and 57% effectiveness against H1N1 and H3N2, respectively.

This study identifies a phosphorylation switch controlled by FGFR1 that regulates GPX4 activity and protects against ferroptosis in cardiac ischemia/reperfusion injury.

This study shows that a mutation in the Drosophila ribosomal protein RpL39 causes embryonic patterning defects by impairing hox gene expression.

The paper develops a genomic ratio to quantify resource-acquisition strategies in bacteria, finding uptake-optimised bacteria dominate early decomposition and depolymerisation-optimised bacteria dominate later stages.

This study identifies PabB as a potential drug target for tuberculosis by pathway analysis and screens FDA-approved drugs for repurposing using molecular docking.

This study shows that sequential vaccination can mature VRC01-class B cells into antibodies that neutralize a broad range of HIV-1 viruses.

This paper uses MALDI-MSI to create the first spatially resolved lipidomic atlas of the human heart, identifying region-specific lipid differences.

This paper evaluates the prediction of SLE using genotype and gene-expression data with batch correction and leakage-free cross-validation, finding that expression data perform better than SNPs but face confounding issues.

The paper identifies horizontal gene transfer of the Drosomycin antimicrobial peptide gene across insect species, suggesting HGT contributes to immune system novelty and defense capabilities.

This study characterizes the anatomy of Arabidopsis hydathodes using imaging techniques, revealing a dense and heterogeneous epithem involved in apoplastic fluid release.

This paper develops a culturomics-guided FMT framework that enables stable, antibiotic-independent engraftment by targeting metabolic niches in recipient microbiomes.

This paper identifies an AKT1-TERT-FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE cells under stress.

The paper identifies an anxiety-related brain network that overlaps with Alzheimer's disease neurodegeneration and is associated with cognitive decline.

The paper investigates how environmental gradients shape microbial community composition by analyzing phylogenetic signals in response to environmental variables.

This study shows that walking speed-accuracy trade-off is driven by energetic optimization rather than motor noise or visual feedback.

SABER improves pose tracking and behavioral analysis in multi-animal videos by integrating identity-preserving tracking with behavioral factor discovery, showing reduced approach behavior in depression-susceptible mice.

Auto-AVS simulates autophagic vacuoles in yeast to test stereological assumptions, finding no effect of body deformation on section statistics but discrepancies in body-number estimates.

The paper identifies BCL11A as a transcription factor that restores differentiation potential in aged oligodendrocyte progenitor cells through computational analysis and experimental validation.

This study shows that PAX6 deficiency in human cerebral organoids leads to an increased inhibitory neuron population and altered excitatory/inhibitory ratio due to dysregulated PTN-PTPRZ1 signaling.