Discover, rate, and discuss biology preprints.

The paper designs lipidoids with controlled lateral spacing of head groups to improve targeting efficiency in lipid-based nanoparticles using EPR methods.

This paper provides a detailed protocol for implementing Mini2P calcium imaging in freely moving mice, covering system setup, optical alignment, and behavioral integration to study neural activity during natural behavior.

This study shows that highly pathogenic coronaviruses induce necroptosis, leading to lung injury, and that inhibiting necroptosis reduces disease severity in mice.

SpaAxFormer improves spatial transcriptomics by integrating gene-level and cell-level representations, achieving better imputation and spatial-domain identification in some datasets.

This study introduces RSMBind, a deep learning model for predicting RNA-small molecule binding sites, achieving high accuracy on benchmark datasets and demonstrating the utility of RNA language models in the absence of structural data.

This study shows that stimulating prefrontal beta oscillations at specific phases improves distinct cognitive functions: response inhibition at peak and working memory at trough.

This study shows that Cxcr2 is essential for mammary gland development by coordinating epithelial-stromal interactions, leading to altered stromal architecture and immune dysregulation.

The paper analyzes how body weight affects the effectiveness of lifespan-extending interventions in mice, finding that heavier mice show greater lifespan benefits.

This study compares two basal forebrain subnuclei in mice, showing they have distinct connectivity and functional recruitment patterns that lead to different cholinergic effects on the cortex.

The paper shows curvature-based schedule ordering remains unchanged in tumors despite treatment-induced selection toward resistance.

The paper shows that learned associations shape neural activity dynamics, enhancing perceptual decisions through anticipatory visual and motor preparation.

The paper shows that SMARCB1 loss disrupts TF-dependent chromatin priming, revealing lineage-specific regulatory output of BAF complexes is constrained by TF repertoire in ATRT tumors.

This study identifies POM121 as a regulator of lentiviral nuclear import, showing its effect is virus-specific and depends on capsid-host interactions.

CoReg is a motion correction tool for in vivo calcium imaging that outperforms existing methods by using tracking-based registration.

This paper introduces PULSE, a context-aware steering method for protein design that improves optimization outcomes by considering sequence-specific directions, and introduces LDS to evaluate trajectory reliability.

SubCellSeg is a 3D segmentation model that outperforms structure-specific models by jointly training on diverse subcellular structures and achieving zero-shot generalization.

The paper identifies plasma B cells as the dominant immune subset in fibrotic hearts of chronic Trypanosoma cruzi-infected mice, revealing their role in sustaining cardiac fibrosis through interactions with fibroblasts.

This study shows that PRDX6's iPLA2 activity protects hepatocarcinoma cells from ferroptosis by maintaining lipid homeostasis and mitophagy.

This study shows that HCMV glycoprotein B, not the pentameric complex, is a target of antibody-mediated phagocytosis, suggesting gB should be prioritized for vaccines against vertical transmission.

CellVocal links spatial context to transcriptional dynamics by integrating spatial RNA velocity with cell-cell communication to attribute cell-state transitions to signalling modules and neighbouring cells.