Laurie E. Littlepage

This study shows that Cxcr2 is essential for mammary gland development by coordinating epithelial-stromal interactions, leading to altered stromal architecture and immune dysregulation.

This paper develops an immunocompetent mouse model of osteoblastic breast cancer bone metastasis using PyMT-CK(OB) cells and validates its utility for studying immune-dependent bone remodeling mechanisms.

This study shows osteoblasts promote breast cancer growth via CXCL5/CXCR2 signaling in 2D and 3D bone-like cultures, with osteoblasts having a stronger effect in 3D models.