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Functional genomic characterization of anti-phage defense systems in vancomycin-resistant Enterococcus faecium

This study identifies anti-phage defense systems in VREfm genomes and finds limited associations between specific systems and phage resistance, with one candidate gene reducing susceptibility.

Concurrent metacognitive evaluation is dissociable from perceptual evidence accumulation in the parietal cortex

This study shows that concurrent uncertainty during decision-making is represented in the parietal cortex but not computed within the same circuit as perceptual evidence accumulation.

Evolution of Vesicle Shape Parameters Based on A Deep-Learning Based Image Analysis Framework Over Extended Time Periods

The paper uses a deep-learning framework to analyze shape dynamics of GUVs over time, measuring morphometric changes and budding behavior.

The Test Used to Choose Between Pesticide Survival Models Tracks Lesion Persistence, Not Hazard Structure

The paper evaluates pesticide survival models by analyzing lesion persistence, showing that post-exposure death rates better reflect hazard structure than peak-based assumptions.

Anticipatory Threat of Shock Reduces the Number of Items Reported From a Brief Visual Display: Evidence for Capacity Loss Along the Scanning Order

The paper shows that anticipating a shock reduces the number of items remembered from a visual display, with greater loss in later positions.

Lung Epithelial TLR7 is a Factor in Viral Replication and Pathogenesis

This study shows that TLR7 in lung epithelial cells drives RSV and influenza replication and disease, but not HPIV3, and links TLR7 expression to sex differences in viral disease.

High-throughput, single-cell-encoded colony imaging reveals infection-linked heterogeneity

HeteroTyper quantifies phenotypic heterogeneity in bacterial colonies across multiple media types, revealing tissue-specific differences and growth dynamics during infection.

The FDA-approved CDK4/6 inhibitor Abemaciclib is a potent agonist of the β-arrestin-biased atypical chemokine receptor ACKR3

This paper identifies abemaciclib, an FDA-approved CDK4/6 inhibitor, as a potent agonist of ACKR3, an atypical chemokine receptor, revealing its ability to modulate chemokine availability and receptor activity.

PIM6 Induces Tolerance and Confers Protection against Mycobacterium tuberculosis in Primary Macrophages

This study shows that PIM6 modulates innate immune responses in macrophages, reducing cytokine production and enhancing bacterial control during Mycobacterium tuberculosis infection.

Disentangling Context-Specific Alzheimer's Disease Progression Signatures through an Explainable AI Framework

ADVISE identifies context-specific Alzheimer's disease progression signatures using an explainable AI framework and validates ROBO2 as a candidate regulator in excitatory neurons.

BioTrajX: evaluating biological plausibility in single-cell trajectory inference

BioTrajX evaluates biological plausibility of single-cell trajectories using three metrics to compare different trajectory inference results.

Enhancers Silence Coupled-coding RNAs in Animals

The paper identifies regulatory non-coding genes marked by nucleosome arginine methylation and regulated by JMJD5, showing their coupling with coding genes in animals.

A population-based resource for the prioritization of rare variants of unknown significance in clinical genomics

The paper identifies rare founder variants in a population and develops a platform for variant prioritization, showing that some pathogenic variants may be missed by conventional methods.

Temporal genomic imprinting regulates grain filling in barley

The paper identifies imprinted genes in barley endosperm and shows how LYS3 regulates grain filling through maternal and paternal allele expression.

One digit too many: brain rhythms and autonomic responses at the limits of working memory capacity

The paper assesses neural and autonomic responses to exceeding digit span by one digit, finding that physiological measures shift in timing and effort rather than showing a clear breakpoint.

Cross-species epigenomic signatures of exceptional longevity: Insights from Jonathan the Giant Tortoise and human centenarians

This study compares epigenomic signatures of longevity between a giant tortoise and humans, finding shared methylation patterns linked to telomere biology.

Basal ganglia output guides decision-making by state destabilization

The paper shows that basal ganglia output in zebrafish destabilizes neural activity states to guide decision-making in a Go/No-go task.

Context-dependent effects of ketamine on emotional evidence integration

This study examines how ketamine affects emotional evidence integration in changing environments, finding it shifts the balance between recent and past information based on volatility.

gcat, its_a_scam: modular tools for single cell data processing and per-cellquality control

The paper introduces gcat and its_a_scam, modular tools for single cell genomic data processing and quality control, showing they produce results comparable to proprietary pipelines.

Physical sensorimotor contingencies facilitate learning in monkeys

This study shows that rhesus monkeys learn maze-solving tasks significantly faster in a physical environment than in a virtual one, with limited performance transfer between the two.