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ANABOLIC FAILURE, NOT CATABOLIC ACTIVATION, UNDERLIES GLYCOGEN DEPLETION IN CERVICAL CARCINOGENESIS: A MULTI-COHORT TRANSCRIPTOMIC ANALYSIS

Pain Matters: Nociceptive signaling drives neural encoding of inflammatory responses

The paper shows that nociceptive signaling is essential for the brain to represent and replay inflammatory states using human fMRI and mouse activity mapping.

Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance

This study shows that inflammatory activation impairs microglial degradation of protein aggregates by creating a lysosomal bottleneck, without affecting their uptake.

LplA-mediated rescue of lethal myopathy and cardiomyopathy in mitochondrial lipoylation-deficient mammalian caused by Lipt1

This study uses AAV-delivered LplA to rescue lethal mitochondrial lipoylation defects in Lipt1-deficient mice, improving survival, motor function, and cardiac health.

Synthetic lethality of p97 inhibition and PSMC2-overexpressionovercomes bortezomib resistance in multiple myeloma

This study identifies PSMC2 overexpression as a driver of bortezomib resistance in multiple myeloma and shows that combining p97 inhibition with bortezomib overcomes this resistance.

Sensory representation by non-equilibrium flows of neural activity at the mesoscale of cortex

This paper introduces a non-equilibrium theory of sensory perception using activity flows in cortical columns, showing that small-number fluctuations are essential for effective representation.

FoXSight: Facilitating Computational Hit Identification in Crystallographic Fragment Screening Experiments

FoXSight identifies weak binding events in crystallographic fragment screening by detecting target-specific density features in noisy electron density maps.

Latent Transforming Growth Factor Binding Protein-2 promotes microfibrillar TGF-β bioavailability to drive pathologic fibrosis in remote regions of infarcted hearts

This study shows that LTBP2 promotes fibrosis in remote myocardium after MI by sequestering latent TGF-β, and its deletion reduces fibrosis and improves cardiac function.

Structural Determinants of Ligand-Mediated Hmg2 Mallostery

This study identifies structural features of Hmg2 that mediate GGPP-dependent misfolding and regulation, revealing that GGPP binding occurs in the transmembrane domain and loops in the lumenal domain transmit the response.

Neural discrimination of emotional prosody in natural sentences in 2- to 3-month-old infants using OPM-MEG

This study uses OPM-MEG to show 2-3 month-old infants can distinguish happy and angry prosody in natural sentences, with neural discrimination occurring 346-454 ms after sentence onset.

Ancient U/V sex chromosomes reveal slow expansion of recombination suppression in Polytrichaceae mosses.

This study analyzes ancient U/V sex chromosomes in Polytrichaceae mosses, showing that recombination suppression has limited SDR expansion and functional degeneration despite their 124 million-year-old origin.

Material-driven fibronectin assembly enables low-dose BMP-2 to regenerate structurally mature bone in critical-sized load-bearing defects

This study shows that PEA-coated monetites functionalized with fibronectin and low-dose rhBMP-2 promote structurally mature bone regeneration in critical-sized defects.

Visual-cortex-projecting neurons in mouse auditory cortex show distinct audiovisual responses independent of motor-related activity

The paper identifies AC-to-V1 projecting neurons in mice and shows they have distinct audiovisual responses independent of motor activity.

An Efficient Microfluidic Platform for Organ-Specific CyclicMultiaxial Loading and Differentiation of Progenitor Cells

This paper introduces a microfluidic platform for applying multiaxial mechanical loading to cell-laden scaffolds, demonstrating its ability to promote cardiac tissue organization and contractile activity.

Gentamicin impairs nephron development in iPSC-derived kidney organoids and disrupts proximal tubular lysosomal function

Herboxidiene and EGFR expression in A172 glioblastoma cells

This study investigates how herboxidiene affects EGFR expression and proliferation in A172 glioblastoma cells, finding that it inhibits growth without causing intron 2 retention seen in lung adenocarcinoma cells.

Stochastic and Heritable Responses in Cell-Size Regulation and Survival to pH Stress in C. glutamicum

This study examines how C. glutamicum cells respond to pH stress by tracking cell size and survival, revealing stochastic and heritable differences in acid and alkaline stress survival.

Sodium arsenite requires redox sensitization to cause developmental dopaminergic neurotoxicity in Caenorhabditis elegans

This study shows that sodium arsenite requires additional mitochondrial or redox stress to cause dopaminergic neurotoxicity in C. elegans, but not fluoroacetic acid.

Reaction-time asymmetry covaries with shifts in hand choice in macaques

This study shows that macaque hand choice and reaction time are influenced by target position, hand displacement, head rotation, and gaze direction, similar to human behavior.

An LRH-1 agonist reverses hepatic metabolic dysfunction in obesity

This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.