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This study identifies how MAFB and MAF work together to shape human anti-inflammatory macrophage identity through IL-10 autocrine signaling and distinct functional roles.

The paper reassesses whether SGLT2 inhibitors directly activate PANK1 and finds they do not, challenging the proposed cardioprotective mechanism.

The paper analyzes age-related fibrosis in human choroid plexus and finds a negative correlation between fibrosis stages and lipid droplet presence in epithelial cells.

The paper identifies a GLRX2 mutation causing mitochondrial dysfunction and somersaulting behavior in Darwin's pigeons, showing how domestication can expose deleterious variants.

The paper identifies RE ripples that synchronize hippocampal and prefrontal activity during NREM sleep, suggesting a role in memory consolidation.

The paper tests Darwin and Wallace's hypotheses on sexual dichromatism in birds using iridescent coloration data, finding support for both but stronger evidence for Darwin's hypothesis.

This study identifies ancestry-specific peripheral immune cell shifts in Alzheimer's disease across multi-ethnic cohorts using RNA-seq and deconvolution methods.

The paper shows that continuous ancestry profiles better capture genetic ancestry complexity than categorical labels, using genotyped data from 28,332 individuals.

This paper develops a luciferase reporter system to measure ester prodrug delivery and hydrolysis in mycobacteria, showing that permeation and intracellular unmasking depend on chain length and branching, respectively.

This study investigates the extracellular morphology and behavior of choanoflagellates to infer traits of their last common ancestor with animals.

The paper identifies ciliated keratinocytes as a pro-inflammatory cell state in psoriasis and atopic dermatitis, showing their association with disease activity and response to treatment.

This study evaluates TACK compounds Pyr01 and Pyr02 for their ability to selectively eliminate HIV-1-infected macrophages, finding Pyr01 effectively targets infected cells while sparing uninfected ones.

The paper examines how thermal similarity within bird genera affects the strength of Bergmann's rule, finding that higher thermal similarity correlates with weaker body size temperature relationships.

This study maps the epigenomic circuits in pleural mesothelioma, identifies potential transcription factors and regulatory elements, and suggests their relevance to epigenetic editing strategies.

The paper characterizes glucosinolate chemodiversity in Cardamine hirsuta accessions and wild-collected material, identifying genetic sources of variation in glucosinolate composition across organs and accessions.

DynamicsPLM predicts protein variant effects by integrating evolutionary and biophysical dynamics, achieving state-of-the-art accuracy with a parameter-efficient model.

The study investigates whether selective auditory attention affects speech-like distortion product otoacoustic emissions (DPOAEs) in competing voices, finding no attentional modulation across stimulus types.

MAUDE-Py replicates and enhances the MAUDE platform for CRISPR screen analysis, offering faster execution and improved visualization tools.

This study uses scRNA-seq to identify transcriptional signatures in CD4+ T cells from beryllium-exposed patients, revealing upregulated immune response genes and downregulated metabolic pathways.