Jiahe Zang

The paper reassesses whether SGLT2 inhibitors directly activate PANK1 and finds they do not, challenging the proposed cardioprotective mechanism.

The paper presents structures of hTRPC3 in resting and open states, revealing how the moonwalker mutation activates the channel by disrupting a polar interaction and inducing structural changes.

This paper introduces a peptide-based method to solubilize eukaryotic membrane proteins without detergents, enabling high-resolution structural studies.

Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.