Lei Chen

This study reveals the structural mechanism of electron transfer in iNOS using cryo-EM, showing how FMND moves to shuttle electrons from FAD to haem via W366.

This paper identifies centipede toxins SpTx1 and Sm3a as inhibitors of human pancreatic KATP channels, revealing their binding mechanism and therapeutic potential for neonatal diabetes.

This paper introduces a peptide-based method to solubilize eukaryotic membrane proteins without detergents, enabling high-resolution structural studies.

Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.

The paper determines the structure of HBsAg at 3.6 Å resolution, revealing how monomers form dimers as the basic unit of SVPs.