Rachita Dash

This paper develops a luciferase reporter system to measure ester prodrug delivery and hydrolysis in mycobacteria, showing that permeation and intracellular unmasking depend on chain length and branching, respectively.

This study investigates the structure-activity relationship of griselimycin, identifying key amino acids and modifications that enhance its antitubercular activity.

This paper introduces D-CLAP, a split-luciferin assay to measure real-time cytosolic accumulation of compounds in live mycobacteria, showing that modifying carboxylates increases accumulation and antimycobacterial activity.

The paper evaluates how structural modifications like macrocyclization and N-alkylation affect peptide accumulation in Mycobacterium tuberculosis using a novel assay, showing macrocyclization generally enhances accumulation while N-alkylation has context-dependent effects.

The paper introduces the CHAMP assay to measure cytosolic drug accumulation in mammalian cells, showing how molecular structure affects penetration.

This paper introduces a luciferase-based assay to measure antibiotic permeability into the cytosol of Gram-negative bacteria and demonstrates its ability to track intracellular accumulation in real time.