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This paper introduces a wireless headstage for simultaneous cortical, muscle, and movement recordings in freely moving mice, demonstrating its utility in seizure detection and behavior-related neural activity analysis.

This study identifies mQTLs for serum and urine metabolites across ancestries, revealing ancestry-specific genetic effects and linking them to disease traits.

The paper develops a spatial proteomics workflow to study early astrocytic remodeling in an ALS mouse model, finding that motor neurons are surrounded by GFAP-high environments earlier than previously observed.

This study shows that maternal separation alters cerebellar circuitry and synaptic plasticity, leading to behavioral and neurobiological deficits in mice.

This study determines the atomic structure of mycobacteriophage SWU1 using cryo-EM, revealing key architectural features critical for virion assembly and infection.

This study shows that vitamin B3 supplementation protects mitochondria from antibiotic-induced damage, preserving bioenergetics and thermogenesis in Drosophila and human cells.

The paper uses in vivo single-cell CRISPR screens to study how tumor suppressor loss and genetic perturbations affect glioma states and immune recruitment in mice.

The paper investigates whether urban-rural differences in selection or pollen limitation explain a flower colour cline in Hesperis matronalis, finding no significant effects.

This paper introduces evidence-based re-identification to correct tracking mistakes in multi-animal behavior studies, showing improved reliability over time compared to existing methods.

This study shows that antigen-specific CD8+ T cells reduce atherosclerotic plaque burden and stabilize plaques by decreasing secondary necrosis and CD47 expression on foam cells.

This study investigates how ribosome-mediated protein folding imposes sequence constraints by analyzing mutations in E. coli DHFR using deep mutational scanning and fluorogenic sensors.

The paper identifies structural determinants in TrxA that confer its essentiality in Synechocystis, showing that its function cannot be replaced by other thioredoxins despite similar abundance.

This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.

This study identifies consistent connectivity, spectral, and spatial changes in intrinsic brain networks in major depression across independent cohorts.

This study identifies Tfcp2l1 and Thrap3 as regulators of ESC self-renewal through exon-5 splicing of Jmjd1c and DNA repair pathway choice.

This study examines sleep architecture differences between Heliconius melpomene and Dryas iulia, linking them to variations in memory investment.

This study identifies a pathogenic MYRF variant causing isolated nanophthalmos by showing it is cleavage deficient, mislocalized, and reduces transcriptional activity with SOX10.

The paper introduces a model to classify brain dynamics based on chronnectome complexity, showing high accuracy in distinguishing cognitive states and age-related changes.

PRISM simultaneously decontaminates ambient RNA and corrects doublets in spatial transcriptomics data, achieving high accuracy and purity in a mouse cerebellum dataset.