Z. Ma

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

This study uses single-cell transcriptomics to analyze GBM tumor microenvironment, identifying immunosuppressive macrophage subtypes and exhausted NK cells, suggesting therapeutic targets.

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

This study shows that microbiota from young mice reduces age-related gout susceptibility by increasing butyric acid and modulating uric acid metabolism in aged mice.

The structure and diversity of the bacterial community in the overlying water of the Yangzong Lake in Yunnan

This study analyzes bacterial community structure and diversity in Yangzong Lake overlying water using high-throughput sequencing, finding variations in physicochemical factors and dominant taxa across sampling sites.

ORF48 is required for optimal lytic replication of Kaposis Sarcoma-Associated Herpesvirus

This study shows ORF48 is essential for KSHV lytic replication by inhibiting the cGAS-STING pathway and blocking innate immune signaling.

Generative AI for Cardiac Organoid Florescence Generation

This paper uses conditional GANs to colorize brightfield images of cardiac organoids, providing cell type-specific fluorescence information to enhance their characterization.

Signatures of innovation and selection in the extremotolerant yeast Kluyveromyces marxianus

This study identifies molecular and genetic features underlying stress resistance in the extremotolerant yeast Kluyveromyces marxianus through omic profiling and evolutionary analysis.

TopoDiff: Improving Protein Backbone Generationwith Topology-aware Latent Encoding

TopoDiff improves protein backbone generation by using a topology-aware latent encoding to enhance controllability and coverage of generated structures.

NS2B-D55E and NS2B-E65D Variations are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks

This study compares the training effects of different Dectin-1 ligands on human monocytes and finds that zymosan induces a distinct phenotype compared to β-glucan through differential activation of signaling pathways.

Phenotypic plasticity of antibiotic resistance, metabolism byproduct utilization and the evolution of mutually beneficial cooperation in Escherichia coli

The paper shows that antibiotic-resistant E. coli can protect sensitive strains from antibiotics and that metabolic byproducts like indole can create mutualistic cooperation between resistant and sensitive strains.

Large-scale lensless microscopy with fast acquisition and region-wise focusing

This paper develops a fast acquisition and region-wise focusing strategy for lensless microscopy, achieving high-resolution imaging of biological samples with reduced acquisition and reconstruction times.

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

This study shows imidacloprid causes developmental delay in honey bee larvae by disrupting molting regulation and nutrient energy metabolism.

GATA3 ZnF2-defective mutant condensation underlies type I IFN-activating in breast cancer

This study shows that ZnF2-defective GATA3 mutations impair LLPS and DNA binding, reducing breast cancer progression and enhancing type I IFN signaling.

Migratory herbivorous waterfowl track multiple resource waves during spring migration

This study shows East Asian herbivorous waterfowl use both seed and green waves during spring migration, with species-specific strategies depending on body size and location.

High Resolution Salmonella Subtyping by the MLSTnext Method

The paper introduces a high-resolution Salmonella subtyping method using MLSTnext-NGS, which efficiently identifies serovars and resolves mixed strains in food samples.

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C

This study shows MUC13 regulates tight junction proteins and intestinal barrier integrity through Protein Kinase C, with deletion of MUC13 increasing TJ protein levels and altering barrier function.

CD73 generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitis

This study shows CD73-generated adenosine reduces neutrophil-driven tissue damage and metaplasia in pancreatitis by promoting inflammation resolution.

More than 90% of nacre matrix proteins are composed of silk-like proteins

The paper identifies silk-like proteins as the main components of nacre matrix proteins, showing over 90% composition in both soluble and insoluble fractions.

Phase separation of Myc differentially regulates gene transcription

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

The Optimal Combination of Scanning Speed and Fiber-to-Stone Distance for Effective and Efficient Dusting during Holmium: YAG Laser Lithotripsy

This study identifies the optimal scanning speed and fiber-to-stone distance for maximizing dusting efficiency during Holmium: YAG laser lithotripsy by comparing photothermal ablation and cavitation effects.

Selective degradation of an ER stress-induced protein by ER-associated degradation mechanism during stress recovery

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells

This study shows that female mice have stronger and more diverse antibody responses to influenza vaccination, leading to better protection against mutant viruses due to increased germinal center B cell activity.

Co-expression of recombinant human collagen α1(III) chain with viral prolyl 4-Hydroxylase in P. pastoris GS115

This study co-expresses recombinant human collagen α1(III) chain with viral prolyl 4-hydroxylase in P. pastoris GS115 and confirms successful expression and secretion of the hydroxylated collagen.

Deterministic evolution and stringent selection during pre-neoplasia

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

Eicosanoids in the pancreatic tumor microenvironment: a multicellular, multifaceted progression

The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.

Loss of epigenetic regulation disrupts lineage integrity, reactivatesmultipotency and promotes breast cancer

This study identifies epigenetic regulators as tumor suppressors in breast cancer by showing their loss leads to lineage infidelity and reactivation of lactation programs.

Pan-cancer organoid validation of tumor outlier chromosomal amplification events

The paper validates oncogenic chromosomal amplification events across multiple cancers using organoid models and functional assays.

Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

Non-Invasive Confocal Fluorescence Imaging of Mice Beyond 1700 nm Using Superconducting Nanowire Single-Photon Detectors

This paper develops a non-invasive imaging technique using NIR-IIc light to image deep tissues in mice, achieving imaging depths of ~800 m and visualizing immune structures in lymph nodes.

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury

The paper uses single-cell RNA sequencing to identify a conserved metaplasia program in pancreatic injury, revealing mucin/ductal populations and neoplastic transformation potential.