Y. Li

This study identifies molecular mechanisms of Quizartinib resistance in FLT3 mutants using molecular dynamics simulations and experimental validation, showing distinct electrostatic and hydrophobic effects of D835Y and F691L mutations.

This study identifies Tfcp2l1 and Thrap3 as regulators of ESC self-renewal through exon-5 splicing of Jmjd1c and DNA repair pathway choice.

This paper introduces a wearable BCI system using AI to mitigate car sickness through attention shifting, showing over 83% effectiveness in reducing symptoms.

This study identifies BEST4 as a tumor suppressor in colorectal cancer that interacts with Hes4 to inhibit EMT and metastasis.

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

The paper develops a deep learning framework to map genotypes to fitness, applies it to predict viral mutations and immune escape, and computes the genotype-fitness landscape for SARS-CoV-2.

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

This study shows that microinfarcts in mice enhance recurrent stroke severity via NLRP3-dependent trained immunity in microglia.

This study shows that inhibiting stromal Class I HDACs reduces pancreatic cancer progression by targeting desmoplastic and pro-tumorigenic programs in cancer-associated fibroblasts.

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

This study identifies small molecule inhibitors of Them1, showing they enhance fatty acid oxidation and reduce glucose production in liver cells, suggesting therapeutic potential for NAFLD.

This study examines changes in physicochemical properties and microbial communities during leaf stacking fermentation, identifying key metabolites and microbial interactions.

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

This paper develops a rotavirus reverse genetics platform enabling exogenous gene insertion and a high-throughput neutralization assay to study immune responses.

This study develops a multiscale model showing that polymerization force-regulated actin-Arp2/3 interactions enable cells to adaptively migrate through heterogeneous ECMs via opposing feedback mechanisms.

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

This paper develops a microfluidic chemostatic bioreactor for high-throughput screening of microalgal growth and lipid production, achieving higher throughput and efficiency compared to traditional methods.

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

The paper was withdrawn due to a conflict of interest and is not intended for citation.

This paper develops a targeted photodynamic approach to neutralize SARS-CoV-2 by enhancing antibody efficacy through singlet oxygen generation.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.