Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- NeurosciencebioRxivPreprint
Functional ultrasound imaging in free-moving marmosets reveals that intra-call prosodic features modulate large-scale cortical dynamics
Xiaochun Cheng, Yichao Luo, Bingqing Wang…·Zhifeng Liang
This study uses functional ultrasound imaging in marmosets to show that intra-call prosodic features influence large-scale cortical dynamics during vocal interactions.
- Plant BiologybioRxivPreprint
NRT2.2 is essential for nitrate uptake and carbon-nitrogen balance in Nannochloropsis oceanica
Anna Santin, Laura Verdesca, Alessandra Bellan…·Alessandro Alboresi
This study identifies NRT2.2 as the primary nitrate transporter in Nannochloropsis oceanica and shows its critical role in nitrate uptake and carbon-nitrogen balance.
DOI 10.64898/2026.11.02.763162 - BioinformaticsbioRxivPreprint
A comparison of two culture and three sequencing methods for detection of the urobiome
Mark Khemmani, Melline Fontes Noronha, Thythy Pham…·Alan J Wolfe
This study compares five methods for detecting the urobiome in urine samples, finding that shotgun metagenomic sequencing provides the broadest species-level view, while culture methods have specific strengths.
DOI 10.64898/2026.10.28.762191 - Cell BiologybioRxivPreprint
Msp300 Links Autophagy to Nuclear Morphodynamics
Shristi Sharma, Ioannis P Nezis
This study identifies Msp300 as a novel interactor of Atg8a in Drosophila, linking autophagy to nuclear architecture through the LINC complex.
DOI 10.64898/2026.11.02.763579 - NeurosciencebioRxivPreprint
Dyskinesia induced by a dopamine 2 receptor-like agonist, but not a dopamine 1 receptor-like agonist, is blocked by sub-anesthetic ketamine
Raveena Parmar, Jasmine R. Meredith, Mitchell J. Bartlett…·Torsten Falk
This study shows that sub-anesthetic ketamine reduces dyskinesia caused by D2R-like receptor agonists but not D1R-like receptor agonists in L-DOPA-primed rats.
DOI 10.64898/2026.10.27.762361 - ImmunologybioRxivPreprint
Serial intravascular labeling resolves dynamic decidual NK residency and gestational remodeling toward T-bet-Low states
Mona A Mohamed, Jessica Vazquez, Marco A Cordero…·Aleksandar K Stanic
This study uses serial intravascular labeling to show dynamic changes in decidual NK cell residency and T-bet expression during pregnancy.
DOI 10.64898/2026.10.28.762610 - NeurosciencebioRxivPreprint
DPYD links glial lipids and myelination to sleep duration
Amber J Zimmerman, Samantha Deal, Erika Almeraya Del Valle…·Allan I Pack
This study identifies DPYD's role in sleep regulation through glial lipid metabolism and myelination across species, linking genetic variants to oligodendrocyte-specific control.
- Cell BiologybioRxivPreprint
Serotonin signals through ciliary 5-HT6 to control insulin secretion
Shannon E Townsend, Jeong Hun Jo, Morgan Opp…·Jing W. Hughes
This study shows that the 5-HT6 receptor in pancreatic beta cells, localized to cilia, enhances insulin secretion, highlighting ciliary localization as a key determinant of GPCR function.
DOI 10.64898/2026.10.30.763155 - PhysiologybioRxivPreprint
Locus Coeruleus activity correlates with transient elevations in breathing during opioid-induced respiratory depression
Caroline C. Szujewski, Jaseph Soto-Perez, Anmin Yang…·Alfredo J. Garcia
This study shows that fentanyl increases locus coeruleus bursts and transient breathing elevations, with divergent respiratory responses after repeated opioid use.
DOI 10.64898/2026.11.02.763547 - Cancer BiologybioRxivPreprint
PERTURBATION OF THE AMINO ACID STRESS RESPONSE PATHWAY EXPOSES A METABOLIC VULNERABILITY IN MULTIPLE AGGRESSIVE CANCER SUBTYPES
Evelien Peeters, Igor Fijalkowski, Sara T'Sas…·Steven Goossens
This study shows that disrupting the amino acid stress response pathway reduces tumor growth in multiple aggressive cancers by targeting chronic metabolic stress adaptation.
DOI 10.64898/2026.11.02.763650 - NeurosciencebioRxivPreprint
Predicting cortical signal mixing in coarse-resolution fMRI: a forward-operator analysis of surface mapping and the conditional benefit of correction
This paper develops a forward-operator model to predict signal mixing in fMRI and shows that correcting for it improves coarse-resolution cortical mapping.
- Plant BiologybioRxivPreprint
CO2-concentrating nanoparticles drive progressive photosynthetic and cell-wall remodelling in Arabidopsis thaliana cells
Cyril Routier, Denise Pagliara, Anna Karlsson…·Eleni Stavrinidou
The paper shows that CO2-concentrating nanoparticles modify photosynthesis and cell wall structure in Arabidopsis cells over time.
DOI 10.64898/2026.10.30.763161 - Developmental BiologybioRxivPreprint
Species-specific WNT requirements shape somite morphogenesis in mammalian embryo models
Charlotte Knight, Luke Simpson, Cinzia Allegrucci…·Ramiro Alberio
This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.
- BiochemistrybioRxivPreprint
Mapping the sequence determinants of constitutive activity in GPCRs
Matthew K Howard, Sara Whiteman, Patrick Rockefeller Grimes…·Willow Coyote-Maestas
The paper measures basal activity across the human GPCR family on a single scale and identifies key residues that influence constitutive signaling.
DOI 10.64898/2026.10.30.762644 - ImmunologybioRxivPreprint
Antibiotics drive immunometabolic rewiring of human immune responses
Shelly Hen-Avivi, Noa Bossel Ben-Moshe, Ravit Avera…·Roi Avraham
This study examines how antibiotics affect immune cell function by altering mitochondrial activity, showing antibiotic-specific immunomodulatory effects in humans and mice.
- MicrobiologybioRxivPreprint
Gut microbiome-associated adaptability of suckermouth catfish inhabiting the polluted Buriganga River: insights into heavy-metal-remediating microorganisms
Sujan Dey, Sumaita Alam Sikder, Mohsina Rahman…·Md. Zobaidul Alam
This study identifies heavy-metal-remediating bacteria in the gut microbiome of suckermouth catfish from the polluted Buriganga River, highlighting their potential for bioremediation.
DOI 10.64898/2026.11.03.763882 - Animal Behavior & CognitionbioRxivPreprint
Ranging and territoriality in African Apes
Martin Surbeck, Rebecca Supple, Anthony P Massaro…·Michael L Wilson
The paper compares ranging and territoriality among African apes, finding that economic defendability does not fully explain interspecific variation in territorial behavior.
DOI 10.64898/2026.11.03.763879 - Cancer BiologybioRxivPreprint
ANABOLIC FAILURE, NOT CATABOLIC ACTIVATION, UNDERLIES GLYCOGEN DEPLETION IN CERVICAL CARCINOGENESIS: A MULTI-COHORT TRANSCRIPTOMIC ANALYSIS
Oyedele Oyewumi Ajayi, Efosa Bolaji Odigie, Samson Oluwaseyi Adesite…·Uchechukwu Brian Eziagu
DOI 10.64898/2026.11.02.763436 - NeurosciencebioRxivPreprint
Pain Matters: Nociceptive signaling drives neural encoding of inflammatory responses
Megan Sammons, Rani Assa Polansky, Itay Zayalat…·Asya Rolls
The paper shows that nociceptive signaling is essential for the brain to represent and replay inflammatory states using human fMRI and mouse activity mapping.