Efficient Inhibition of O-glycan biosynthesis using the hexosamine analog Ac5GalNTGc
S.-S. Wang, V. del Solar, X. Yu, A. Antonopoulos, A. E. Friedman, K. Agarwal, M. Garg, S. M. Ahmed, A. Addhya, M. Nasirikenari, J. T. Lau, A. Dell, S. M. Haslam, S.-G. Sampathkumar, S. Neelamegham
This paper demonstrates that Ac5GalNTGc is a potent inhibitor of O-glycan biosynthesis, effectively reducing O-glycan elongation and modulating leukocyte functions.
bioRxiv · Dec 13, 2020Biochemistry