Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease
E. Saponara, C. Penno, M. L. Matadamas Guzman, V. Brun, B. Fischer, M. Brousseau, Z.-Y. Wang, P. ODonnell, J. Turner, A. Graff Meyer, L. Bollepalli, G. dArio, G. Roma, W. Carbone, V. Orsini, , H. Ruffner
This study shows that deleting Lgr4/5 in mouse livers disrupts Wnt/β-catenin signaling, leading to fatty liver disease and fibrosis.
bioRxiv · Nov 22, 2021Physiology