Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.
L. Cottone, L. Ligammari, H. J. Knowles, H.-M. Lee, S. Henderson, S. Bianco, C. Davies, S. Strauss, F. Amary, A. P. Leite, R. Tirabosco, K. Haendler, J. L. Schultze, J. Herrero, P. ODonnell, , A. M. Flanagan
This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.
bioRxiv · Dec 27, 2021Cancer Biology