Author

F. Nigsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. Roma· 2 shared J. Tchorz· 2 shared V. Orsini· 2 shared W. Carbone· 2 shared A. Aebi· 1 shared A. Basler· 1 shared A. Graff Meyer· 1 shared A. Osmont· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

G. Roma

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry

M. Pikusa, O. Rene, S. Williams, Y.-L. Chen, E. Martin, W. J. Godinez, S. P. S. Rao, A. W. Guiguemde, F. Nigsch

This paper uses AI-driven generative chemistry to design a novel molecule active against Chagas disease parasites, validated experimentally.

bioRxiv · Dec 10, 2021 · PreprintPharmacology & Toxicology

Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease

E. Saponara, C. Penno, M. L. Matadamas Guzman, V. Brun, B. Fischer, M. Brousseau, Z.-Y. Wang, P. ODonnell, J. Turner, A. Graff Meyer, L. Bollepalli, G. dArio, G. Roma, W. Carbone, V. Orsini, , H. Ruffner

This study shows that deleting Lgr4/5 in mouse livers disrupts Wnt/β-catenin signaling, leading to fatty liver disease and fibrosis.

bioRxiv · Nov 22, 2021Physiology

Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis

R. Ungricht, L. Guibbal, M.-C. Lasbennes, V. Orsini, M. Beibel, A. Waldt, R. Cuttat, W. Carbone, A. Basler, G. Roma, F. Nigsch, J. Tchorz, D. Hoepfner, P. S. Hoppe

This study uses genome-wide CRISPR screening in human kidney organoids to identify novel regulatory mechanisms in nephrogenesis, including a new role for Jagged1 in controlling epithelial proliferation.

bioRxiv · May 26, 2021Cell Biology