B. Fischer

Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid adaptive radiation

The paper analyzes 1,375 Malawi cichlid genomes to show that sex-linked chromosomal inversions drive adaptive speciation through introgression and selection on neuro-sensory, physiological, and reproductive genes.

A pangenomic perspective of the Lake Malawi cichlid radiation reveals extensive structural variation driven by transposable elements

The paper uses a pangenomic approach to analyze Lake Malawi cichlid genomes, revealing extensive structural variation driven by transposable elements.

Nanobody CDR3 mimetics enhance SOS1-catalyzed nucleotide exchange on RAS

This study shows that CDR3 mimetics can enhance SOS1-catalyzed nucleotide exchange on RAS, demonstrating functional modulation of protein-protein interactions through structural mimicry of a nanobody.

Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

The paper introduces methods to discover Nanobodies that modulate SOS1-RAS interactions and nucleotide exchange rates, with potential applications in drug design.

From Pigs to Silkworms: Cognition and Welfare across 10 Farmed Taxa

The paper develops a cross-taxa framework to assess cognition and welfare ranges in farmed animals using behavioral and cognitive proxies.

Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease

This study shows that deleting Lgr4/5 in mouse livers disrupts Wnt/β-catenin signaling, leading to fatty liver disease and fibrosis.

Differential use of multiple genetic sex determination systems in divergent ecomorphs of an African crater lake cichlid

The paper identifies three coexisting sex-determining alleles in two ecomorphs of Astatotilapia calliptera, showing genetic interactions affecting fitness and speciation.

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

The paper introduces megabodies, engineered nanobodies that improve cryo-EM resolution by addressing particle size and orientation issues, and demonstrates their application in solving a membrane protein structure.

Emphasizing the ‘positive’ in positive reinforcement: Using non-binary rewarding for training monkeys on cognitive tasks

This paper introduces a non-binary rewarding scheme for training monkeys on cognitive tasks, which accelerates training without compromising task difficulty or performance.