Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
X. Huang, H. Hu, A. Webster, F. Zou, J. Du, K. Fejes Toth, A. Aravin, S. Li
The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.
bioRxiv · Jul 14, 2020Biochemistry