F. Zou

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells

This study shows that KUS121 reduces atherosclerosis by maintaining ATP levels and reducing ER stress in endothelial cells.

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells.

This study shows that murine VL30 retrotransposons can be inadvertently transferred to CAR-T cells via γ-retroviral vectors, raising biosafety concerns.

Improved Metabolite Prediction Using Microbiome Data-Based Elastic Net Models

The paper develops ENVIM, an Elastic Net Model-based method for predicting metabolites from microbiome data, showing improved accuracy over existing methods in oral, gut, and vaginal microbiome datasets.

Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.

Infection risk and extensive parental care govern the molecular evolution of Toll-like receptors in birds.

This study examines the molecular evolution of Toll-like receptor genes in birds, finding that positive selection is linked to migration, parental care, and body size.