H. Hu

Structural insights into the in situ assembly of clustered protocadherin γB4

This study investigates the in situ assembly of cPcdh-γB4 using electron tomography, revealing distinct roles of ectodomain and intracellular domain in intermembrane organization.

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

Bacterial metabarcoding reveals plant growth promoting members of the core Brachypodium distachyon root-associated microbiome overlooked by culture dependent techniques

This study combines bacterial metabarcoding and culture-based techniques to identify plant growth promoting bacteria in Brachypodium distachyon root microbiomes, revealing strains overlooked by traditional methods.

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

Delta-5 elongase knockout reduces DHA and TAG synthesis coupled with an increase of heat sensitivity in a marine diatom

This study shows that knocking out delta-5 elongase in a marine diatom reduces DHA and TAG synthesis and increases heat sensitivity.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

Global abundance patterns, diversity, and ecology of Patescibacteria in wastewater treatment plants

The paper improves 16S rRNA gene primers to better detect Patescibacteria in wastewater treatment plants, revealing their global diversity and potential ecological roles.

Adaptive diversification through structural variation in barley

This study presents a barley pangenome revealing structural variation linked to traits like disease resistance and plant architecture, highlighting its role in adaptive evolution.

A removable and cosmopolitan dsRNA Toti-like virus causes latent infection in a model diatom strain

The paper identifies a dsRNA Totiviridae virus in two diatom strains, shows it can be removed to create virus-free lines, and suggests it causes latent infection rather than lytic infection.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Platelet-specific TGFβ1 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

SARS-CoV-2 Omicron BA.2.86: less neutralization evasion compared to XBB sub-variants

This study compares the immune evasion of SARS-CoV-2 Omicron BA.2.86 to XBB sub-variants, finding BA.2.86 shows less neutralization evasion.

Neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from ZF2001 RBD-dimer and its next-generation vaccines

This study evaluates the neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from vaccinated individuals and breakthrough infections, finding that next-generation vaccines offer better protection against these variants.

Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

Tafazzin Mediates Tamoxifen Resistance by Regulating Cellular Phospholipid Composition in ER-Positive Breast Cancer

This study identifies Tafazzin's role in tamoxifen resistance by regulating phospholipid composition in ER+ breast cancer cells, showing that TAZ depletion promotes resistance via an LPC-LPA axis.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

Berberine reduce inflammation in RA rats through MCP1/CCR2 pathway

This study shows berberine reduces inflammation in RA rats by modulating the MCP1/CCR2 pathway, decreasing joint swelling and inflammatory markers.

Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma

The paper develops an automated in vitro sonodynamic therapy system for glioblastoma and demonstrates its efficacy in inducing apoptosis and reducing 3D growth of glioma cells.

Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology

The paper designs transmembrane proteins that inhibit the erythropoietin receptor by competing with homodimerization in a custom binding topology.

The structural basis of itch receptor MRGPRX1 activation

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

Mechanisms of ion selectivity and rotor coupling in the bacterial flagellar sodium-driven stator unit

This study determines the structure of the Na+-driven bacterial flagellar stator unit PomAB, revealing mechanisms of ion selectivity, rotor coupling, and stator unit activation.

Identification of differential polypharmacology between the PARP inhibitor rucaparib and its major metabolite

This study identifies differential polypharmacology between rucaparib and its metabolite M324, showing distinct kinase inhibition profiles with potential clinical implications.

Exosome-mediated viral nucleic acid presentation in a crustacean reveals innate immunity evolution from a novel perspective

The paper shows that DNA virus components are packaged into exosomes by infected crustacean cells, which transmit apoptotic signals to suppress viral spread.

Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production

This study uses optogenetic feedback control to regulate the unfolded protein response in yeast, improving protein production yields by 60%.

Cultivation of widespread Bathyarchaeia reveals a novel methyltransferase system utilizing lignin-derived aromatics

This study cultivates a Bathyarchaeia strain capable of degrading lignin via a novel methyltransferase system, suggesting its role in global anaerobic lignin remineralization.

Transcriptomic analysis of seed development in Paysonia auriculata (Brassicaceae) identifies genes involved in hydroxy fatty acid biosynthesis and seed maturation