Channeling macrophage polarization via selective translation inhibition by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
S. Chatterjee, S. M. Yabaji, B. Bhattacharya, E. Waligurski, N. Vallavoju, S. Ray, L. E. Brown, A. B. Beeler, A. R. Ivanov, L. Kobzik, J. A. Porco, I. Kramnik
This study shows rocaglates shift macrophage polarization toward M1-like by inhibiting IL-4 response and enhancing resistance to Mycobacterium tuberculosis.
bioRxiv · Aug 31, 2020 · PreprintImmunology