BiochemistrybioRxiv
The Cyclimids: Degron-inspired cereblon binders for targeted protein degradation
S. Ichikawa, N. C. Payne, W. Xu…·C. M. Woo
This study introduces cyclimids, degrons derived from CRBN, which show improved selectivity and potency in targeted protein degradation by forming ternary complexes with CRBN and substrates.
DOI 10.1016/j.chembiol.2024.01.003