Author

L. Kobzik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. Kramnik· 5 shared S. M. Yabaji· 4 shared B. Bhattacharya· 3 shared S. Chatterjee· 3 shared B. N. Kholodenko· 2 shared N. Crossland· 2 shared O. S. Rukhlenko· 2 shared P. B. Araveti· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

I. Kramnik

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

S. M. Yabaji, V. Zhernovkov, P. B. Araveti, S. Lata, O. S. Rukhlenko, S. A. Abdullatif, A. Vanvalkenburg, Y. Alekseev, Q. Ma, G. Dayama, N. C. Lau, W. E. Johnson, W. R. Bishai, N. A. Crossland, J. D. Campbell, , I. Kramnik

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

bioRxiv · Mar 5, 2024Immunology

Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung

S. M. Yabaji, S. Lata, A. E. Tseng, P. B. Araveti, M. Lo, I. Gavrish, A. K. O'Connel, H. P. Gertje, A. Belkina, C. E. Thurman, H. Kiyokawa, D. N. Kotton, S. Tan, J. J. Endsley, W. R. Bishai, , I. Kramnik

This study identifies aberrant macrophage activation and maladaptive lung repair as key factors promoting tuberculosis progression in the lung using a novel mouse model.

bioRxiv · Oct 17, 2023 · PreprintImmunology

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov, O. S. Rukhlenko, K. Seidel, B. Bhattacharya, S. Chatterjee, H. A. Chen, N. Crossland, W. Bishai, B. N. Kholodenko, A. Gimelbrant, L. Kobzik, I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

bioRxiv · Dec 14, 2020 · PreprintImmunology

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

Z. Inde, C. Yapp, G. N. Joshi, J. Spetz, C. Fraser, B. Deskin, E. Ghelfi, C. Sodhi, D. Hackam, L. Kobzik, B. Croker, D. Brownfield, H. Jia, K. A. Sarosiek

The paper examines age-related changes in ACE2 expression and apoptosis regulation in lung tissue, linking these to differences in COVID-19 severity across age groups.

bioRxiv · Sep 13, 2020Cell Biology

Channeling macrophage polarization via selective translation inhibition by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

S. Chatterjee, S. M. Yabaji, B. Bhattacharya, E. Waligurski, N. Vallavoju, S. Ray, L. E. Brown, A. B. Beeler, A. R. Ivanov, L. Kobzik, J. A. Porco, I. Kramnik

This study shows rocaglates shift macrophage polarization toward M1-like by inhibiting IL-4 response and enhancing resistance to Mycobacterium tuberculosis.

bioRxiv · Aug 31, 2020 · PreprintImmunology

The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

B. Bhattacharya, S. Xiao, S. Chatterjee, M. Urbanowski, A. Ordonez, E. A. Ihms, G. Agrahari, S. Lun, R. Berland, A. Pichugin, Y. Gao, J. Connor, A. Ivanov, B.-S. Yan, L. Kobzik, , I. Kramnik

This study identifies the integrated stress response (ISR) as a mediator of necrosis in tuberculosis granulomas, showing that ISR inhibition reduces bacterial burden and necrosis in susceptible mice.

bioRxiv · Dec 19, 2018 · PreprintImmunology