Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
L. Ma, S. K. Sahu, M. Cano, V. Kuppuswamy, J. Bajwa, J. McPhatter, A. B. Pine, M. M. Meizlish, G. Goshua, C. H. Chang, H. Zhang, C. Price, P. Bahel, H. M. Rinder, T. Lei, , H. S. Kulkarni
The paper shows that complement activation is higher in severe SARS-CoV-2 infection compared to influenza and non-COVID respiratory failure, with the alternative pathway linked to worse outcomes.
bioRxiv · Feb 22, 2021Immunology