Author
Primary ORCID profile (0000-0002-5563-7418 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
T. Zhang, T. Lei, J. Han, R. Zhang, W. Shen, Y. Liu, Y. Liao, Q. He, Y. Zhao, X. Zhang, R. Yan, Q. He, Y. Chen, H. Pan, L. Wang, , X. Chen
This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.
bioRxiv · Sep 24, 2023 · PreprintBioengineering
W. B. Alsoussi, S. K. Malladi, J. Q. Zhou, Z. Liu, B. Ying, W. Kim, A. J. Schmitz, T. Lei, S. C. Horvath, A. J. Sturtz, K. M. McIntire, B. Evavold, F. Han, S. M. Scheaffer, I. F. Fox, , A. H. Ellebedy
This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.
Nature · Apr 3, 2023Peer-reviewedImmunology
W. Kim, J. Q. Zhou, A. J. Sturtz, S. C. Horvath, A. J. Schmitz, T. Lei, E. Kalaidina, M. Thapa, W. B. Al Soussi, A. Haile, M. K. Klebert, T. Suessen, L. Parra-Rodriguez, P. A. Mudd, W. D. Middleton, , A. H. Ellebedy
This study tracks the maturation of B cell responses to SARS-CoV-2 vaccination, showing that memory B cells and bone marrow plasma cells accumulate somatic hypermutations over time, enhancing antibody avidity.
bioRxiv · Oct 31, 2021 · PreprintImmunology
Y. Qian, Z. Wang, H. Lin, T. Lei, Z. Zhou, W. Huang, X. Wu, L. Zuo, J. Wu, Y. Liu, L.-F. Wang, X.-H. Guan, K.-Y. Deng, M. Fu, H.-B. Xin
This study shows TRIM47 enhances endothelial activation and pulmonary inflammation by promoting K63-linked ubiquitination of TRAF2, leading to NF-κB and MAPK pathway activation.
bioRxiv · Sep 15, 2021 · PreprintCell Biology
P. A. Mudd, A. A. Minervina, M. V. Pogorelyy, J. S. Turner, W. Kim, E. Kalaidina, J. Petersen, A. J. Schmitz, T. Lei, A. Haile, A. M. Kirk, R. C. Mettelman, J. C. Crawford, T. H. O. Nguyen, L. C. Rowntree, , A. Ellebedy
This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.
bioRxiv · Sep 8, 2021Immunology
A. J. Schmitz, J. S. Turner, Z. Liu, I. D. Aziati, R. E. Chen, A. Joshi, T. L. Bricker, T. L. Darling, D. C. Adelsberg, W. B. Al Soussi, J. B. Case, T. Lei, M. Thapa, F. Amanat, J. A. O'Halloran, , A. H. Ellebedy
A vaccine-induced human monoclonal antibody neutralizes SARS-CoV-2 and variants, reducing lung inflammation and viral load in hamsters.
bioRxiv · Mar 24, 2021Immunology
L. Ma, S. K. Sahu, M. Cano, V. Kuppuswamy, J. Bajwa, J. McPhatter, A. B. Pine, M. M. Meizlish, G. Goshua, C. H. Chang, H. Zhang, C. Price, P. Bahel, H. M. Rinder, T. Lei, , H. S. Kulkarni
The paper shows that complement activation is higher in severe SARS-CoV-2 infection compared to influenza and non-COVID respiratory failure, with the alternative pathway linked to worse outcomes.
bioRxiv · Feb 22, 2021Immunology
Y. Qian, T. Lei, P. Patel, C. Lee, P. Monaghan-Nichols, H.-B. Xin, J. Qiu, M. Fu
This study identifies SARS-CoV-2 nucleocapsid protein as a potent activator of human endothelial cells, showing that simvastatin inhibits this activation through TLR2/NF-κB and MAPK pathways.
bioRxiv · Feb 14, 2021Immunology
Y. Lei, J. Zhang, C. R. Schiavon, M. He, L. Chen, H. Shen, Y. Zhang, Q. Yin, Y. Cho, L. Andrade, G. S. Shadel, M. Hepokoski, T. Lei, H. Wang, J. Zhang, , J. Y.-J. Shyy
This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.
bioRxiv · Dec 4, 2020Pathology
P. T. Ly, A. Lucas, S. H. Pun, A. Dondzillo, C. Liu, A. Klug, T. Lei
This paper introduces a robotic stereotaxic system using 3D skull reconstruction to enhance the accuracy and speed of small-animal brain surgeries while reducing experimental failure rates.
bioRxiv · Jan 4, 2020Bioengineering