A. Day

Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans

This study identifies stress-dependent changes in Hog1 pathway regulation in C. albicans, revealing Ssk1's role as a scaffold and its impact on Hog1 phosphorylation under different stress conditions.

Critical analysis of polycyclic tetramate macrolactam biosynthetic cluster phylogeny and functional diversity

This study analyzes PTM biosynthetic clusters to uncover their phylogenetic diversity and functional complexity, revealing gaps in bioinformatics predictions and highlighting challenges in genomic discovery.

Selection of Ethanol Tolerant Strains of Candida albicans by Repeated Ethanol Exposure Results in Strains with Reduced Susceptibility to Fluconazole

This study shows that repeated ethanol exposure of Candida albicans leads to strains with increased ethanol tolerance and reduced fluconazole susceptibility.

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

The paper characterizes the proteome and phosphoproteome of prostate cancer patient-derived xenografts to identify differences between neuroendocrine-like and adenocarcinoma subtypes.

Saracatinib synergizes with enzalutamide to downregulate androgen receptor activity in castration resistant prostate cancer

This study shows that combining saracatinib with enzalutamide reduces androgen receptor activity and DNA replication in CRPC cell lines, leading to increased apoptosis.

Structure of a dominant negative mutant reveals a stalled intermediate in anthrax protective antigen pore maturation

The paper identifies a dominant negative mutation that stalls anthrax protective antigen pore maturation at an intermediate state, revealing structural features and a regulatory mechanism for pore formation.

Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids

This study uses lipidomic profiling to characterize sphingolipids in MSCs from different sources and identifies sex- and stimulation-dependent differences in ceramide levels linked to immune modulatory potency.

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.

The paper shows that complement activation is higher in severe SARS-CoV-2 infection compared to influenza and non-COVID respiratory failure, with the alternative pathway linked to worse outcomes.

Isolation and characterisation of watermelon (Citrullus lanatus) extracellular vesicles and their cargo

This study isolates and characterizes watermelon extracellular vesicles, showing they are distinct from cellular debris and have potential roles in plant development and metabolism.