C. Frezza

SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer

SiRCle integrates multi-omics data to identify regulatory mechanisms and survival-associated markers in clear cell renal cell carcinoma.

Multi-omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

The paper identifies metabolites and genes associated with squamous cell lung cancer using multi-omic data and validates their expression in tumors and cell lines.

Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression

This study shows that inhibiting asparagine synthetase (ASNS) with antisense oligonucleotides reduces kidney volume and improves renal function in PKD mice by targeting metabolic pathways.

Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues.

This paper uses Raman micro-spectroscopy to directly detect and map fumarate distribution in living cells and tissues, revealing its compartmentalization and distinguishing Fh1-deficient cells.

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

FOXA2 controls the anti-oxidant response in FH-deficient cells

This study identifies FOXA2 as a key transcription factor regulating the anti-oxidant response in FH-deficient cells, independent of NRF2, and highlights its role in metabolic rewiring.

HIRA loss transforms FH-deficient cells

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.

This study identifies Fbxo7's role in promoting Cdk6 activity to inhibit PFKP and glycolysis in T cells, revealing its impact on metabolism and viability.

Macrophage Innate Training Induced by IL-4 and IL-13 Activation Enhances OXPHOS Driven Anti-Mycobacterial Responses

This study shows that IL-4 and IL-13 activation of macrophages induces protective innate memory against mycobacterial infection through enhanced OXPHOS-driven pro-inflammatory responses.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

The paper shows that early neutrophilia driven by aerobic glycolysis supports host metabolism and delays cancer cachexia in murine models.

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

ABHD11 regulates 2-oxoglutarate abundance by protecting mitochondrial lipoylated proteins from lipid peroxidation damage

The paper identifies ABHD11 as a mitochondrial hydrolase that protects lipoylated proteins from lipid peroxidation, thereby regulating 2-OG levels and 2-OG DD function.

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

This study shows that IKKε, a breast cancer oncogene, reprograms mitochondrial function and serine metabolism independently of its canonical signaling role, promoting cancer cell proliferation.

CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolism.

This study shows CHCHD4 promotes tumour cell proliferation and suppresses EMT through complex I-mediated mitochondrial metabolism.

Tumor pre-conditioning of draining lymph node stroma by lactic acid

This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.