A. Basseville

BCL-xL antagonizes the deleterious effects of KRAS on mitochondrial scaffolding

This study shows BCL-xL prevents KRAS from disrupting mitochondrial scaffolding by maintaining proximity to prohibitin 2 and preventing mitochondrial mass decrease.

Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cells

This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.

Targeting of MCL-1 in breast cancer associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties

This study shows that targeting MCL-1 in breast cancer-associated fibroblasts reduces their myofibroblastic traits and pro-invasive properties.