M. Levine

Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug

This study shows that pharmacological ascorbate induces transient hypoxia in pancreatic ductal adenocarcinoma, enhancing the efficacy of the hypoxia-activated prodrug evofosfamide in some tumor models.

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

The genomic landscape, causes, and consequences of extensive phylogenomic discordance in Old World mice and rats

This study investigates phylogenomic discordance in Old World mice and rats, finding that genetic linkage and selection influence phylogenetic patterns and that assuming a single species tree can lead to errors in detecting positive selection.

Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

This study identifies subclonal copy number alterations in relapsed osteosarcoma, showing MYC gain/amplification in treatment-resistant clones and their emergence before chemotherapy.

Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cells

This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

Cellular aging in vitro recapitulates multi-tissue epigenetic aging in vivo

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

Accelerated single cell seeding in relapsed multiple myeloma

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.

Diversification and collapse of a telomere elongation mechanism

The paper examines telomere elongation mechanisms in Drosophila species, finding diversification and collapse of retrotransposon lineages and a shift to recombination-based telomere maintenance.