Author

C. Sourbier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

A. Basseville· 1 shared B. Oliver· 1 shared C. J. Ricketts· 1 shared D. E. Farthing· 1 shared D. L. Sackett· 1 shared D. Motabar· 1 shared D. T. Gallagher· 1 shared E. Kim· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. Basseville

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Detecting Features of Protein Structure through their Mediator-Accessible Redox Activities

D. Motabar, E. Kim, J. Li, Z. Zhao, T. Mouchahoir, D. T. Gallagher, J. E. Schiel, M. Garige, C. Sourbier, G. F. Payne, W. E. Bentley

This paper introduces an electronic detection method to identify structural perturbations in proteins by measuring mediator-accessible redox activities, demonstrating its application in biomanufacturing.

bioRxiv · Dec 12, 2023 · PreprintBioengineering

Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cells

A. Basseville, P.-C. Violet, M. Safari, C. Sourbier, M. Linehan, R. W. Robey, M. Levine, D. L. Sackett, S. E. Bates

This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.

bioRxiv · Jan 31, 2022Cancer Biology

Glycolytic metabolism of pathogenic T cells enables early detection of GvHD by 13C-MRI

J. C. Assmann, D. E. Farthing, K. Saito, N. Maglakelidze, B. Oliver, K. A. Warrick, C. Sourbier, C. J. Ricketts, T. J. Meyer, S. Z. Pavletic, W. M. Linehan, M. C. Krishna, R. E. Gress, N. P. Buxbaum

This study uses 13C-MRI to detect early glycolytic activity in T cells, enabling non-invasive GvHD detection before symptoms appear.

bioRxiv · Mar 16, 2020Immunology