M. Safari

This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.

The paper investigates how overlapping genes in HIV-1 balance selective forces, finding functional segregation where each protein spaces its residues to accommodate the other's functional sites.

This paper identifies CK1 delta as an mRNA cap-associated protein that drives translation initiation and tumor growth in blood cancers, with distinct roles in solid tumors.

This study investigates the phase behavior of mutant p53, showing it forms mesoscopic liquid clusters that facilitate amyloid fibril nucleation and revealing that structural destabilization drives condensation.