A. Janshoff

Cell-substrate distance fluctuations of confluent cells enable fast and coherent collective migration

The paper examines how cell-substrate distance fluctuations affect collective migration in confluent monolayers of MDCKII cells and their ZO1/2-depleted variants.

Impact of native-like lipid membranes on the architecture and contractility of actomyosin networks

This study investigates how phosphatidylserine affects actomyosin network contractility by modulating ezrin binding and actin filament interactions in a lipid membrane model.

Cellular segregation in co-cultures driven by differential adhesion and contractility on distinct time scales

This study investigates how differential adhesion and contractility drive time-dependent segregation in epithelial co-cultures, showing contractility dominates short-term sorting while adhesion determines the final state.

Membrane interactions of mitochondrial lipid transfer proteins

This study investigates how Ups1 interacts with mitochondrial membranes, showing its preference for positively curved membranes and its role in phosphatidic acid transfer.

WNT11 is a novel ligand for ROR2 in human breast cancer

The paper identifies WNT11 as a novel ligand for ROR2 in breast cancer, showing it promotes invasion through RHO/ROCK signaling and forms an auto-stimulatory loop.

The role of actin and myosin II in the cell cortex of adhered and suspended cells

This study investigates how actin and myosin II dynamics, structure, and mechanics differ between adhered and suspended cells, revealing unexpected correlations and new localization patterns of NMII minifilaments.

Viscoelasticity of basal plasma membranes and cortices derived from MDCK II cells

This study measures the viscoelastic properties of basolateral membranes from MDCK II cells and compares them to apical membranes, finding they are stiffer but follow the same scaling law.

The role of PI(4,5)P2 and synaptotagmin in membrane fusion - an in vitro study

This study investigates how PI(4,5)P2 and synaptotagmin-1 interact to facilitate membrane fusion in vitro, showing increased fusion efficiency with calcium and PIP2.

Tight junction ZO proteins maintain tissue fluidity, ensuring efficient collective cell migration

This study shows ZO proteins maintain tissue fluidity and control proliferation to enable efficient collective cell migration.

Pre-stress of actin cortices is important for the viscoelastic response of living cells

This study investigates how pre-stress in actin cortices affects the viscoelastic properties of living cells using a novel model and atomic force microscopy.

Vimentin intermediate filaments undergo irreversible conformational changes during cyclic loading

This study shows vimentin intermediate filaments undergo irreversible conformational changes under cyclic loading, introducing a third state to explain their mechanical behavior.

An intact keratin network is crucial for mechanical integrity and barrier function in keratinocyte cell sheets

This study shows that keratin networks are essential for mechanical integrity and barrier function in keratinocytes, with keratin deficiency causing impaired wound closure and dysfunctional barriers.