Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
K. H. Smith, A. Budhraja, J. Lynch, K. Roberts, J. C. Panetta, J. P. Connelly, M. E. Turnis, S. M. Pruett-Miller, J. D. Schuetz, C. Mullighan, J. T. Opferman
The paper identifies the heme-sensing pathway as a regulator of MCL-1 expression in B-lineage acute leukemia, showing that modulating this pathway enhances sensitivity to BH3-mimetics.
bioRxiv · Apr 10, 2020Cancer Biology