Author

A. Bugai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Barboric· 2 shared A. F. Arutyunyan· 1 shared A. Hassinen· 1 shared A. Ianevski· 1 shared A. J. Quaresma· 1 shared A. L. Zhuze· 1 shared A. Waage· 1 shared C. C. Friedel· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

M. Barboric

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

Z. Wang, M. Macakova, A. Bugai, S. G. Kuznetsov, A. Hassinen, T. Lenasi, S. Potdar, C. Friedel, M. Barboric

This study identifies P-TEFb as a factor that promotes cell survival by suppressing the intrinsic apoptosis pathway when p53 is activated, suggesting its potential as a therapeutic target in combination with apoptosis inducers.

bioRxiv · May 29, 2022Biochemistry

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

A. Ianevski, E. Kulesskiy, K. Krpina, G. Lou, Y. Aman, A. Bugai, K. Aasumets, Y. Akimov, D. Bulanova, K. Gildemann, A. F. Arutyunyan, O. Y. Susova, A. L. Zhuze, P. Ji, W. Wang, , D. E. Kainov

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

bioRxiv · Jan 13, 2020Cancer Biology

P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress

A. Bugai, A. J. Quaresma, C. C. Friedel, V. Lenasi, C. R. Sibley, P. Kukanja, K. Fujinaga, M. Blasius, T. Hennig, J. Ule, L. Doelken, M. Barboric

This study shows RBM7 activates P-TEFb to promote cell survival during genotoxic stress by enhancing Pol II elongation and transcription of DDR genes.

bioRxiv · Aug 17, 2018Biochemistry