J. Ule

The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes

This study identifies MAGOH and MAGOHB as oncogenic factors in high-grade gliomas that safeguard splicing of cell division and cell cycle genes, with high expression linked to poor prognosis.

The FXR1 network acts as signaling scaffold for actomyosin remodeling

The paper identifies the FXR1 network as a cytoplasmic mRNA scaffold that facilitates actomyosin remodeling by organizing signaling interactions.

Interrogation of RNA-protein interaction dynamics in bacterial growth

This study characterizes RNA-protein interaction dynamics in Escherichia coli across growth phases, identifying new RNA-binding proteins and their functions.

m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene

This study identifies Nucleolin as a key mediator of RAS-driven ribosome biogenesis and tumorigenesis through enhanced RNA-binding activity.

Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling

This study introduces 13C-dynamods to quantify the turnover of modified ribonucleosides in RNA, revealing distinct kinetic behaviors of m6A and m7G and their responses to stress conditions.

Subcellular mRNA localization regulates ribosome biogenesis in migrating cells

The paper shows that subcellular localization of RP-mRNAs via LARP6 enhances ribosome biogenesis during cell migration and supports cancer progression through EMT.

Lactate potentiates differentiation and expansion of cytotoxic T cells

This study shows that lactate enhances the anti-tumour activity of cytotoxic T cells by increasing their proliferation and cytotoxicity during exercise.

The key protein of endosomal mRNP transport Rrm4 binds translational landmark sites of cargo mRNAs

The transcriptome-wide landscape and modalities of EJC binding in adult Drosophila

The paper identifies EJC binding modalities in Drosophila by developing a method to isolate RNA-bound EJC complexes, revealing canonical binding sites and their association with developmental transcripts.

P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress

This study shows RBM7 activates P-TEFb to promote cell survival during genotoxic stress by enhancing Pol II elongation and transcription of DDR genes.