Author

L. Doelken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:virus· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

T. Hennig· 4 shared A. L'Hernault· 2 shared B. Prusty· 2 shared C. C. Friedel· 2 shared F. Erhard· 2 shared A. Bugai· 1 shared A. Grothey· 1 shared A. J. Quaresma· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

T. Hennig

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Building Blocks of Understanding: Constructing a Reverse Genetics Platform for studying determinants of SARS-CoV-2 replication.

M. Olguin-Nava, P. Bohn, T. Hennig, C. Boertlein, A.-S. Gribling-Burrer, N. Schmidt, N. Caliskan, L. Doelken, M. Munschauer, R. P. Smyth

This paper develops a reverse genetics platform for SARS-CoV-2 to generate recombinant viruses and study their replication and phenotypic effects.

bioRxiv · Feb 5, 2024 · PreprintMicrobiology

Decoding murine cytomegalovirus

M. Lodha, I. Muchsin, C. Jürges, V. Juranic Lisnic, A. L'Hernault, A. Rutkowski, B. Prusty, A. Grothey, A. Milic, T. Hennig, S. Jonjic, C. Friedel, F. Erhard, L. Doelken

This paper reannotates MCMV gene expression using multi-omics data, identifying hundreds of novel transcripts and ORFs, including small ORFs that regulate gene expression and a new immediate-early transcript.

bioRxiv · Nov 10, 2022 · PreprintMicrobiology

Integrative functional genomics decodes herpes simplex virus 1

A. W. Whisnant, C. S. Juerges, T. Hennig, E. Wyler, B. Prusty, A. J. Rutkowski, A. L'Hernault, M. Goebel, K. Doering, J. Menegatti, R. Antrobus, N. J. Matheson, F. W. Kuenzig, G. Mastrobuoni, C. Bielow, , L. Doelken

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.

bioRxiv · Apr 9, 2019Microbiology

P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress

A. Bugai, A. J. Quaresma, C. C. Friedel, V. Lenasi, C. R. Sibley, P. Kukanja, K. Fujinaga, M. Blasius, T. Hennig, J. Ule, L. Doelken, M. Barboric

This study shows RBM7 activates P-TEFb to promote cell survival during genotoxic stress by enhancing Pol II elongation and transcription of DDR genes.

bioRxiv · Aug 17, 2018Biochemistry