Author

Y. Akimov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

D. Bulanova· 2 shared K. Wennerberg· 2 shared T. Aittokallio· 2 shared A. Bugai· 1 shared A. F. Arutyunyan· 1 shared A. Ianevski· 1 shared A. L. Zhuze· 1 shared A. Waage· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

D. Bulanova

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 14, 2022

A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing drugs in RB1-deficient ovarian and breast cancer cells

D. Bulanova, Y. Akimov, W. Senkowski…·K. Wennerberg

This study identifies CK2 inhibition as a sensitizing strategy for RB1-deficient ovarian and breast cancer cells to replication-perturbing drugs, showing enhanced efficacy when combined with existing therapies.

DOI 10.1101/2022.11.14.516369

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivJan 13, 2020

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

A. Ianevski, E. Kulesskiy, K. Krpina…·D. E. Kainov

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

DOI 10.3390/cancers12061694

C. eleganshuman

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 29, 2019

DNA barcode-guided lentiviral CRISPRa tool to trace and isolate individual clonal lineages in heterogeneous cancer cell populations

Y. Akimov, D. R. Bulanova, M. Abyzova…·T. Aittokallio

This paper introduces a DNA barcode-guided CRISPRa tool for tracing and isolating individual clonal lineages in cancer cell populations, enabling unbiased analysis of subclonal evolution.

DOI 10.1101/622506

humangenetic perturbation / CRISPR

𝕏 PostBluesky