BiochemistrybioRxiv
An intrinsically disordered transcription activation domain alters the DNA binding affinity and specificity of NFκB p50/RelA
H. E. R. Baughman, D. Narang, W. Chen…·E. A. Komives
This study shows that the RelA TAD increases NFκB-DNA binding affinity but reduces specificity for κB sequences by enhancing non-specific DNA binding.
DOI 10.1016/j.jbc.2022.102349