BiophysicsbioRxiv
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket
C.-Y. Huang, A. Metz, R. Lange…·A. Mac Sweeney
This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.
DOI 10.1107/s2059798324000329