D. Ritz

Bacterial RNA promotes proteostasis through inter-tissuecommunication in C. elegans

The paper shows that bacterial-derived RNA extends healthspan in C. elegans by reducing protein aggregation through inter-tissue communication and systemic RNAi.

Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

Molecular control of endurance training adaptation in mouse skeletal muscle

The paper identifies molecular changes in mouse skeletal muscle due to endurance training and shows how training status affects transcriptional and proteomic responses to acute exercise.

Adipose mTORC2 is essential for arborization of sensory neurons in white adipose tissue and whole-body energy homeostasis

The paper identifies adipose mTORC2's role in sensory neuron arborization in white adipose tissue and links it to systemic insulin resistance.

Photoaffinity capture compounds to profile the Magic Spot Nucleotide interactomes

The paper identifies Magic Spot Nucleotide interactomes in E. coli and S. typhimurium using photoaffinity capture compounds, revealing new targets like ApaH.

Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and Zeitgeber activity of endurance training

The paper investigates how exercise timing affects circadian rhythms and endurance performance in mice, finding time-dependent differences in metabolic and signaling pathways.

Abiotic drivers of protein abundance variation among natural populations

This study links protein abundance variation in natural caddisfly populations to abiotic environmental factors, showing that protein responses are shaped by their functional roles and environmental conditions.

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia

The paper shows that loss of Hexokinase 2 in adipose tissue due to high fat diet leads to hyperglycemia through systemic glucose homeostasis disruption.